Unless low-risk people are getting shots twice a year too, I don't see this as reaching the goals that are as monumental as the article and Gilead suggests. Su

Unless low-risk people are getting shots twice a year too, I don't see this as reaching the goals that are as monumental as the article and Gilead suggests. Sure, vaccinating high risk sexually active preteens in regions of Africa will dramatically reduce infection in ways that have been insurmountable to those on the frontlines. But for everyone else, this doesn't seem to materially change anything. A sexually active adult or accidental/intentional polycule in western nations has no change in user experience. The risk remains both low and essentially the same. Test often if you are in "sex-positive" communities where testing and sharing results isn't taboo. Or do nothing and just imagine you're being responsible. Its the same as before. PreP users can switch to a 2x yearly regime instead of the current frequency, but that's only for people with partners already. I just don't see this as good enough unless it turns into like a one time vaccination, done as part of a cocktail in a normal routine checkup.