If you set up multiple TCP connections over Wireguard, there is no head-of-line blocking either. And Wireguard also transitions across network changes. In fact

If you set up multiple TCP connections over Wireguard, there is no head-of-line blocking either. And Wireguard also transitions across network changes. In fact, it's one of the main reasons I use Wireguard. I can transition between mobile network and wifi without any of the applications noticing.