3 ms·

Unfortunately there is no approved oral medicine to lower Lp(a) that I am aware of. (I mean given a normal LDL.) Statins don't lower it afaik. An oral medicine

Unfortunately there is no approved oral medicine to lower Lp(a) that I am aware of. (I mean given a normal LDL.) Statins don't lower it afaik. An oral medicine named muvalaplin is being tested for it.

throwaway7783 1y ago
There are some in trials. I'm part of one by Eli Lily. Lp(a) sucks, is genetic and so far there was no medication.
- dr_ 1y ago
  The best way to get tested may be in conjunction with a trial. This was can potentially enroll.
_zagj 1y ago
Oddly enough, there's evidence that saturated fat intake inversely affects Lp(a) levels: https://pmc.ncbi.nlm.nih.gov/articles/PMC10447465/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10447465/
- OutOfHere 1y ago
  It doesn't help if LDL gets raised due to the SFAs, as LDL is an independent risk factor.
  - _zagj 1y ago
    I was just noting the oddness of Lp(a) responding inversely to SFA intake (the reverse of LDL), which also contradicts the conventional wisdom that Lp(a) isn't amenable to lifestyle interventions. You could theoretically increase SFA to target Lp(a) while still using lipid-altering drugs to target LDL.
d4704 1y ago
I’ve read that (injection currently, not oral) ‘PCSK9 inhibitors’ may help lower Lp(a) where few other things do today. https://my.clevelandclinic.org/health/drugs/22550-pcsk9-inhibitors https://my.clevelandclinic.org/health/drugs/22550-pcsk9-inhi...
brandonb 1y ago
There's a clinical trial for a new drug, lepodisiran, which lowered Lp(a) by 93.9%. Outside of that, if your Lp(a) is high, then the first strategy would be to choose a lower ApoB target than you would otherwise. (Every Lp(a) particle is also an ApoB/cholesterol particle, but 6x more atherogenic. So by lowering ApoB, you are compensating for the effect of high Lp(a)) Summary of the current research/evidence is here: https://www.empirical.health/blog/lipoprotein-a-blood-test/#how-to-lower-lipoproteina-with-medication https://www.empirical.health/blog/lipoprotein-a-blood-test/#...
agensaequivocum 1y ago
This guy talks about lowering his own with collagen and vitamin C https://x.com/gregmushen/status/1917780163242385586 https://x.com/gregmushen/status/1917780163242385586 And another guy lowering his with Amla, lysine and vitamin C https://x.com/gregmushen/status/1924660722786828584 https://x.com/gregmushen/status/1924660722786828584
- OutOfHere 1y ago
  It is nonsense because I have truly taken all four in good daily doses for years, and my value is still high.

throwaway7783 1y ago

There are some in trials. I'm part of one by Eli Lily. Lp(a) sucks, is genetic and so far there was no medication.

dr_ 1y ago
The best way to get tested may be in conjunction with a trial. This was can potentially enroll.

_zagj 1y ago

Oddly enough, there's evidence that saturated fat intake inversely affects Lp(a) levels: https://pmc.ncbi.nlm.nih.gov/articles/PMC10447465/ https://pmc.ncbi.nlm.nih.gov/articles/PMC10447465/

OutOfHere 1y ago
It doesn't help if LDL gets raised due to the SFAs, as LDL is an independent risk factor.
- _zagj 1y ago
  I was just noting the oddness of Lp(a) responding inversely to SFA intake (the reverse of LDL), which also contradicts the conventional wisdom that Lp(a) isn't amenable to lifestyle interventions. You could theoretically increase SFA to target Lp(a) while still using lipid-altering drugs to target LDL.

d4704 1y ago

I’ve read that (injection currently, not oral) ‘PCSK9 inhibitors’ may help lower Lp(a) where few other things do today. https://my.clevelandclinic.org/health/drugs/22550-pcsk9-inhibitors https://my.clevelandclinic.org/health/drugs/22550-pcsk9-inhi...

brandonb 1y ago

There's a clinical trial for a new drug, lepodisiran, which lowered Lp(a) by 93.9%. Outside of that, if your Lp(a) is high, then the first strategy would be to choose a lower ApoB target than you would otherwise. (Every Lp(a) particle is also an ApoB/cholesterol particle, but 6x more atherogenic. So by lowering ApoB, you are compensating for the effect of high Lp(a)) Summary of the current research/evidence is here: https://www.empirical.health/blog/lipoprotein-a-blood-test/#how-to-lower-lipoproteina-with-medication https://www.empirical.health/blog/lipoprotein-a-blood-test/#...

agensaequivocum 1y ago

This guy talks about lowering his own with collagen and vitamin C https://x.com/gregmushen/status/1917780163242385586 https://x.com/gregmushen/status/1917780163242385586 And another guy lowering his with Amla, lysine and vitamin C https://x.com/gregmushen/status/1924660722786828584 https://x.com/gregmushen/status/1924660722786828584

OutOfHere 1y ago
It is nonsense because I have truly taken all four in good daily doses for years, and my value is still high.