Nothing that's not obvious. Surely, there are methods to squeeze more revenue out of Adsense, or any display ad for that matter, but you'll risk being banned.

Nothing that's not obvious. Surely, there are methods to squeeze more revenue out of Adsense, or any display ad for that matter, but you'll risk being banned. So that's not worth it, especially when you get bigger. I do recommend trying out different ad networks and having them compete with each other and with adsense in an ad server such as OpenX or DFP.