6 ms·
Mary had schizophrenia, then suddenly didn't
- bookofjoe 1y agohttps://archive.ph/BTttE https://archive.ph/BTttE
- LoganDark 1y agoI highly doubt there'll ever be research in this area, but I'm very curious about whether it'll ever be possible to induce schizophrenia for a time, similar to how psychedelics or dissociatives can induce altered mind states.
- LorenDB 1y agoWe'll probably get it along with all the other artificially induced injuries: https://antifandom.com/hitchhikers/wiki/Pseudo-fractures https://antifandom.com/hitchhikers/wiki/Pseudo-fractures
- lillecarl 1y agoThe redneck version: Take LSD and stimulants without sleep for days.
- lenerdenator 1y agoMy understanding is that the Liver King, Brian Johnson, is basically doing that right now.
- partomniscient 1y agoNot to be confused with "Don't Die", Bryan Johnson who wants to outlive everyone, and preferred 5-MeO-DMT. Interestingly, he uses immunosuppresants as part of his anti-aging medicine/supplement regime. https://medium.com/@x3em/from-depression-to-superhuman-bryan-johnsons-quest-for-immortality-ef3ebf018a0e https://medium.com/@x3em/from-depression-to-superhuman-bryan... https://www.netflix.com/au/title/81757532 https://www.netflix.com/au/title/81757532
- ivape 1y agoThat’s not the redneck version, that’s the everybody version. You don’t need the LSD even, just pick a stimulant of choice, legal or not (meth, coke, adderral, vyvanse, Ritalin). Ingest it for days, you’ll be in psychosis in no time.
- lillecarl 1y agoYou're absolutely right, I'm quite liberal myself but I've never done more than "two days" for obvious reasons. We're evolutionary designed around earth's rotation so better not fuck too much with it. I was drunk for almost two days once and at the end I couldn't comprehend conversation!
- LoganDark 1y agoI actually have done this (not by choice though), and I guess I might've gotten close to something like psychosis. Maybe I'll push it further when I'm in a less stressful environment. I neglect basic needs too much as it is, hah.
- lillecarl 1y agoIf you want to experience another personality and/or view on things the better thing is Ketamine. Don't fuck with your sleep for some burnt out euphoria experience. Always respect your sleep, it's the only thing keeping you from cooking your brain at 30. Anecdotal but my mate's mom got Alzheimers when shes like 55, an overworked overstressed, never sleeping woman.
- LoganDark 1y agoTaking ketamine sucks. I actually tried with the nasal sprays before and I literally threw the spray bottle in the garbage because of how miserable that was. I didn't even get a meaningful experience out of it, but I burned the ever living fuck out of my throat from how bitter the stuff was. I heard IM injection works far better, but it's probably gonna take a long time for me to work up the courage for that. (Also, I have DID so I experience other personalities all the time!)
- lillecarl 1y agoI'm genuinely surprised, for me it's been doing medative self reflecting work for ages. I buy the shitty powder on $monerosite and systematically prepare a bunch to get into the "pre hole state" with banger ket music in the headphones and closed eyes. It brings 5d chess into my psychology or something
- LoganDark 1y agoI don't think the nasal route is good for me. Brain doesn't like it, body doesn't like it, it just feels extremely miserable. I think I tried it before the ketamine spray, but it would just dry out my nose and it was really painful and it just felt so awful that I couldn't manage to dose myself enough to have a good effect before I just couldn't bear to take any more. It's awful and terrible and I hate it. Which sucks, because I really feel like dissociatives would be nice. I've taken memantine orally and it was nice, although it took really long to wear off, and also after a while it made me throw up all over my expensive tech, which was very not fun. Ketamine though I haven't found an adequate way to take.
- petee 1y agoMy friend in highschool did a solid week on lots of acid and mushrooms, and ended up in the hospital with a schizophrenia diagnosis - this was 20yr ago, but they said he was likely to get it eventually but he triggered something or otherwise sped up the process. So you're probably right, but on both points sadly. To this day he still sends me complex CAD drawings of nothing.
- garciasn 1y agoMushrooms and LSD have high tolerance from 24-96h where higher doses will not reproduce the same effects w/o abstinence. I find it hard to believe that a week's worth of exposure was the sole cause. [s]: https://www.sciencedirect.com/science/article/abs/pii/B9780128002124000790 https://www.sciencedirect.com/science/article/abs/pii/B97801...
- Loughla 1y ago>but they said he was likely to get it eventually but he triggered something or otherwise sped up the process. OP did address that. But Lots of folks attribute things like schizophrenia to hallucinogen use, when in reality, people make questionable decisions in their late teens and early twenties; this is the time that these disorders tend to manifest. So a lot of coincidence leads to a casual relationship in popular culture.
- deleted 1y ago[deleted]
- LoganDark 1y agoIt's genetic predisposition to schizophrenia that enables psychedelics to activate it. Without the genetic predisposition you'd be lucky to get psychosis (or unlucky, as it were). That's why people with a family history of schizophrenia or related mental disorders are particularly encouraged to avoid psychedelics.
- partomniscient 1y agoI agree, most medications will create/change tolerance to more of the same. In some respect that's the purpose of taking some medications in the first place, but it can lead to poor long term outcomes. Take enough melatonin exogenously and your endogenous production stops completely. “I took five people, and we locked ourselves in a building for three weeks, and we took 400 micrograms of LSD every four hours. That is 2400 micrograms of LSD a day.… We finally were just drinking out of the bottle.… We were very high.” From Be Here Now - Ram Dass/Richard Alpert Interestingly he was the guy involved in giving psilocybin to priests back at Harvard in the 1960's. Recent source: https://tripsitter.substack.com/p/ram-dass https://tripsitter.substack.com/p/ram-dass On the other hand, one single dose of a psychiatric medication can ruin peoples lives. They get brain shocks, sexual dysfunction or anhedonia for life. One dose of marijuana can effect similar outcomes. I know immunosuppresants are whole separate part of medicine, but its a playing with fire risk/reward where its too early to establish reasonable probabilities. But at least we can begin the cause-effect discovery process.
- williamscales 1y agoDefinitely seems like the sort of thing that MKUltra would have looked at. Those folks were big into ideas like creating specific mental states in people.
- LoganDark 1y agoI hope one day there'll be branches of medicine for each neurotype rather than just giving up whenever a drug's effects aren't consistent in trial. there needs to be more studies into everything ever
- ejstronge 1y ago> I highly doubt there'll ever be research in this area, but I'm very curious about whether it'll ever be possible to induce schizophrenia for a time, similar to how psychedelics or dissociatives can induce altered mind states. It is not possible, by definition; here’s a portion of the DSM 5 definition of schizophrenia: “ The disturbance is not attributable to the physiological effects of a substance (e.g., a drug of abuse, a medication) or another medical condition” Hard to find a publicly accessible DSM link, but here is an excerpt https://floridabhcenter.org/wp-content/uploads/2021/03/Pages-2019-Psychotherapeutic-Medication-Guidelines-for-Adults_Schizophrenia_06-04-20.pdf https://floridabhcenter.org/wp-content/uploads/2021/03/Pages...
- jvanderbot 1y agoThis is true, but I wonder if GP spoke naively about inducing symptoms that are similar enough that we can learn about what triggers those symptoms in otherwise healthy individuals. Kind of like how we were "lucky" to get a guy with a railroad spike through his brain to learn about how brain damage affects personality and impulsiveness..
- LoganDark 1y agooh it was definitely for selfish reasons, I just want to feel it for myself. But I do have a feeling that it would advance science as well, that'd be a cool bonus I guess.
- epsilonic 1y agoThis attribution criteria might be subject to revision based on research like this: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2829840 https://jamanetwork.com/journals/jamanetworkopen/fullarticle...
- LoganDark 1y ago> It is not possible, by definition I use schizophrenia to refer to the experience, not to the diagnosis. I'm not sure what to call the experience of schizophrenia other than schizophrenia, given it's not synonymous with psychosis. (Though, granted, I would also want to try psychosis someday; even if it's a terrible experience and I never want to do it again, I want to truly know what it's like. Hopefully without permanent brain damage though. That stipulation heavily limits my options.)
- ldoughty 1y agoThis is a long read, so to summarize: A woman developed what we call schizophrenia. She hid it reasonably well, but eventually was hospitalized for it. Later they found cancer. While treating the cancer, her schizophrenia "magically" disappeared. Seemingly for good. The article points that this isn't a unique case, and that schizophrenia, as a "hopeless disease," doesn't get enough attention... And there's no real sub classification to determine what lead to a set of symptoms (which is the only current diagnostic criteria). So the speculation is that autoimmune treatments might cure or help some forms of schizophrenia. Read the full article if this story sounds interesting!
- tmaly 1y agoIt seems like we still have a lot to learn in this field of science.
- nwienert 1y agoThe GLP-1 drugs are strong auto-immune regulators and neuroprotective and show promise with related disease: https://www.mdpi.com/1422-0067/26/6/2741 https://www.mdpi.com/1422-0067/26/6/2741 https://aaic.alz.org/releases-2024/glp-drug-liraglutide-may-protect-against-dementia.asp https://aaic.alz.org/releases-2024/glp-drug-liraglutide-may-... https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14313 https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz... https://pmc.ncbi.nlm.nih.gov/articles/PMC11242057/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11242057/ Some promise for autism and depression, though little with schizophrenia: https://www.psychiatrist.com/pcc/efficacy-glp-1-agonists-psychiatric-illnesses-scoping-review/ https://www.psychiatrist.com/pcc/efficacy-glp-1-agonists-psy... https://www.news-medical.net/news/20250511/GLP-1-receptor-agonists-improve-mood-and-metabolic-health-in-adults-with-mental-illness.aspx https://www.news-medical.net/news/20250511/GLP-1-receptor-ag...
- quantumwoke 1y agoAlzheimer's disease is not schizophrenia.
- RC_ITR 1y agoI also wonder if just that microglia are activated during chemo. Maybe this is just the most useful case of 'chemo brain' ever.
- Kittensmittens3 1y agoSeeing articles like this gives me hope that there is momentum in an eventual trend that will cure mental illness, or treat it with a method that isn't antipsychotics. I personally believe that in the US, our society is quick to demand people seek treatment, even forcibly. Yet the treatment available is insufficient, incredibly destructive and often ineffective.
- xena 1y agoIf you ever want to experience pure hell, go on antipsychotics for a month. They totally eviscerate your ability to be creative. I was given them during a misdiagnosis of mental health issues and I think I'd rather choose to be homeless instead of going back on them for any reason. Also don't make the mistake I did and quit them cold turkey. If you don't taper them off, you can have seizures. Not fun.
- dns_snek 1y agoNot to take away from your own experience at all, but you can't make sweeping statements about psychiatric medication like that. As far as I know most of them are very personal, and it's quite common for any given medication to be a terrible experience for some while it's a life saver for others.
- fragmede 1y agoI'm sorry you had a bad experience with them, but that wasn't my experience. The antipsychotic I am on helps me immensely in not being sucidal and being able to live some semblance of approximating a normal human life.
- Kittensmittens3 1y agoThis is noted as a common and serious side effect that many people experience. Unfortunately it's also noted as a symptom of the common diseases these medications treat. It's seemingly a mess of figuring out what parts of suffering are medication related or disease related. This is why this discovery in the article is so fascinating - science doesn't even know what causes this in the first place, thus it's impossible to decipher which is which. We just know it can address some symptoms in some people and in general some feel the tradeoff is better.
- readthenotes1 1y ago'rituximab, the immunosuppressant. “I have a new working theory,” she texted Angie, in May, 2024. “Theoretically her chemo could have incidentally cured” her. Christine found a handful of recent case studies that documented drastic psychiatric recoveries after people were treated with drugs that dampen immune activity. ' The part I cared about, buried deep
- tacitusarc 1y agoRelatedly, I’m really curious to see if this will get more traction in the coming years. Seems like it’s worth some analysis: https://stephenskolnick.substack.com/p/schizophrenia https://stephenskolnick.substack.com/p/schizophrenia
- NotGMan 1y agoChemo could have modified her gut microbiome. People went on keto diets etc... to heal their psychichiatric issues. Eg the son of the Roblox founder healed his bipolar with a keto diet. https://www.youtube.com/watch?v=ZwXKh7cjALw https://www.youtube.com/watch?v=ZwXKh7cjALw
- siliconc0w 1y agoThere is also some hope that a Ketogenic diet can help treat schizophrenia, maybe acting by a similar mechanism (reducing inflammation)
- carom 1y agoThere are studies that going gluten free has positive health outcomes for schizophrenic patients. I could see keto working by the same mechanism.
- y-curious 1y agoKeto was invented for the treatment of seizures in children, actually. There's a guy I know that killed 2 people with his car when he had a seizure. He's been seizure-free (and obviously not driving, btw) for years since starting keto
- deleted 1y ago[deleted]
- xyzzy123 1y agoYou can also have psychosis / schizophrenia type symptoms triggered by UTIs (urinary tract infections), this is not uncommon in the elderly.
- stefantalpalaru 1y ago[dead]