If your immune system was "boosted" and worked significantly better tomorrow than it does today, would there be large measurable outcomes? No, probably not. U

If your immune system was "boosted" and worked significantly better tomorrow than it does today, would there be large measurable outcomes? No, probably not. Unless you've got something wrong with you, day to day, it would be hard to detect a distinct improvement in an already working system. Getting a good signal-to-noise ratio for a healthy person getting slightly healthier is hard. The bias for not publishing negative results and various sorts of intentional and unintentional p-hacking means that small-effect-size research that showed say "1 gram of vitamin C per day improved x by 5% in healthy adults" wouldn't be that reliable anyway. "dramatic improvement" of ICU sepsis patients isn't something that suffers from p-hacking. Someone dying of sepsis in an ICU though, there's a whole bunch of very clear signals whether something is meaningfully effective or not. What that result tells you is that megadoses of vitamin C are likely not bullshit and should continued to be studied in more and more difficult to detect cases. What this tells me is that 1) because I know it's likely rather safe for me and 2) there's enough evidence to convince me it might help, I'll keep taking lots of vitamin C if I feel like I'm getting sick.