Seeing as this is an in vitro study, they fall back on a specific human study (Witkowski et al., 2023) for many of the human effect claims. However the referenc

Seeing as this is an in vitro study, they fall back on a specific human study (Witkowski et al., 2023) for many of the human effect claims. However the referenced study has a few issues: - All study subjects had a "high prevalence of CVD [cardiovascular disease] and risk factor burden" - Erythritol occurs naturally in the body and and this was not accounted for - The study subjects were already suffering from cardiovascular disease and were likely to be consuming more artificial sweeteners than a general population, but this was not recognized or accounted for - Erythritol's presence after a cardiovascular incident could be from consumption or from natural production but only baseline was measured despite data showing dramatic fluctuations after consumption Another one of the studies cited for evidence of human claims (Khafagy et al., 2024) directly contradicts them. It stated said "we did not find supportive evidence from MR that erythritol increases cardiometabolic disease". There are two more human studies referenced but I didn't read them.