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As I understand it, a human egg has about an equal quantity of nuclear and mitochondrial DNA. The mitochondrial DNA is highly replicated, though (about 100,000
by pfdietz 1y ago
As I understand it, a human egg has about an equal quantity of nuclear and mitochondrial DNA. The mitochondrial DNA is highly replicated, though (about 100,000 mitochondria, each with ~16600 base pairs of DNA).
- burning_hamster 1y agoI was going to call BS on this one, but after crunching some numbers, if anything this is likely an underestimate. human nuclear genome size (haploid): 3.1 billion bp mitochondrial genome size: 16 000 bp 1 human nuclear genome per egg -> 3.1 billion bp nuclear DNA 100 000 mitochondria, each with 1-10 genomes per mitochondrion [1] -> 1.6-16 billion bp mitochondrial DNA So the ratio of mitochondrial to nuclear DNA in human eggs is on the order of 0.5 to 5. [1] https://pmc.ncbi.nlm.nih.gov/articles/PMC4988970/ https://pmc.ncbi.nlm.nih.gov/articles/PMC4988970/
- pfdietz 1y agoThank you for the tidbit that mitochondria each may have multiple copies of that genome.