4 ms·

The study mentions they administered 30 milligrams of psilocybin for 70 kg of body weight. Does anybody know how many grams of dried mushrooms that is equivalen

The study mentions they administered 30 milligrams of psilocybin for 70 kg of body weight. Does anybody know how many grams of dried mushrooms that is equivalent to, roughly?

adamgordonbell 1y ago
2 to 5 grams dried psilocybe cubensis, per chatgpt.
- TrackerFF 1y ago
  You’ll be tripping balls on that amount. 5g is close to a heroic dose. EDIT: Never mind, didn't see that it was cubensis - which might take more due to being weaker than regular wild semilanceata.
  - throwaway330935 1y ago
    I've been doing some recent research and testing, and here's what I have found: I'm talking about the "Penis Envy" strain, which is quoted as being ~30% more potent than typical. 2g is the edge of where I start getting visual artifacting, and only sometimes. 3g, which I have not tried, was quoted as being towards the upper end of a "theraputic dose", and 6g as the upper end of a recreational dose. Some friends with much more experience consider 1g to be microdosing, FWIW. 0.25g I can't feel at all. .5g I start to feel some euphoria and 1g to 1.5g I start to feel "high" but with no noticeable psychedelics or just minor visual artifacting when I'm reading. I don't really have anxiety or depression. I do have a fairly high stress family life, wife and kiddos have lots of issues. A few weeks ago I had 2g on an empty stomach on a Sunday and I just listened to music for ~4 hours and it was like I had a vacation. I hadn't enjoyed listening to music so much for 20-30 years. Also, I seem to feel kind of sleepy when I'm trippy, but afterwards I'm wide awake for 4-5 hours. So evening dosing is best avoided. It's kind of great, for me personally, living in a state where it has been decriminalized.
    - amanaplanacanal 1y ago
      Personal response may vary. At .15 grams of dried mushrooms I can definitely feel effects, while still be able to perform normal life functions.
- mock-possum 1y ago
  And I’d consider about an eighth to be a dose, so that sounds like it’s in the right neighborhood.
  - throwaway330935 1y ago
    I learned from an episode of "The Studio" that by "an eighth" you are likely referring to an eighth of an ounce is around 3.5 grams. Dude thought he got really mild shroom laced chocolates ("an eighth of a gram") and much hilarity ensued.
- scellus 1y ago
  Here's a rough breakdown from Claude: "[...] psilocybin converts to psilocin in the body at roughly a 1:1 ratio by active effect [...] Psilocybe cubensis (most common): Contains about 0.5-1.0% psilocybin by dry weight. Since psilocybin converts to psilocin in the body at roughly a 1:1 ratio by active effect, 30mg of psilocin would be equivalent to roughly 3-6 grams of dried P. cubensis. Psilocybe semilanceata (liberty caps): Much more potent at 1-2% psilocybin content, so you'd need only about 1.5-3 grams dried. Psilocybe azurescens: Even more potent at 1.5-2.5% psilocybin, requiring roughly 1-2 grams dried. Important caveats: - Individual mushrooms within the same species can vary by 3-5x in potency Growing conditions, harvesting time, and drying/storage methods all affect potency - The caps are typically more potent than stems - Fresh vs. dried makes a huge difference (fresh mushrooms are ~90% water)" Have to note that the paper is from 2016; for those really interested, it's good to read recent review papers.
  - sampl3username 1y ago
    @grok is this true????
    - scellus 1y ago
      lol
  - skeezyboy 1y ago
    there was a study recently showing no difference in caps v stems
- locallost 1y ago
  I don't know if that's true or false, but I would certainly not trust chatgpt blindly in this case.
Joel_Mckay 1y ago
That is the problem with clandestine pharmacy by Florida man, as people may get the wrong dose or a mixture of various other poisons like arsenic (see dark web article.) When ready, please talk with your doctor first. =3
awithrow 1y ago
A good ballpark for dried shrooms is roughly 1% psilocybin by weight of dried shroom, so about 3g. That said, it's going to vary a lot shroom to shroom, genetic to genetics, and species to species. Could be as high as 6g for more mild strains and as low a 1g for something like pan cyans.

The study mentions they administered 30 milligrams of psilocybin for 70 kg of body weight. Does anybody know how many grams of dried mushrooms that is equivalent to, roughly?

adamgordonbell 1y ago

2 to 5 grams dried psilocybe cubensis, per chatgpt.

TrackerFF 1y ago
You’ll be tripping balls on that amount. 5g is close to a heroic dose. EDIT: Never mind, didn't see that it was cubensis - which might take more due to being weaker than regular wild semilanceata.
- throwaway330935 1y ago
  I've been doing some recent research and testing, and here's what I have found: I'm talking about the "Penis Envy" strain, which is quoted as being ~30% more potent than typical. 2g is the edge of where I start getting visual artifacting, and only sometimes. 3g, which I have not tried, was quoted as being towards the upper end of a "theraputic dose", and 6g as the upper end of a recreational dose. Some friends with much more experience consider 1g to be microdosing, FWIW. 0.25g I can't feel at all. .5g I start to feel some euphoria and 1g to 1.5g I start to feel "high" but with no noticeable psychedelics or just minor visual artifacting when I'm reading. I don't really have anxiety or depression. I do have a fairly high stress family life, wife and kiddos have lots of issues. A few weeks ago I had 2g on an empty stomach on a Sunday and I just listened to music for ~4 hours and it was like I had a vacation. I hadn't enjoyed listening to music so much for 20-30 years. Also, I seem to feel kind of sleepy when I'm trippy, but afterwards I'm wide awake for 4-5 hours. So evening dosing is best avoided. It's kind of great, for me personally, living in a state where it has been decriminalized.
  - amanaplanacanal 1y ago
    Personal response may vary. At .15 grams of dried mushrooms I can definitely feel effects, while still be able to perform normal life functions.
mock-possum 1y ago
And I’d consider about an eighth to be a dose, so that sounds like it’s in the right neighborhood.
- throwaway330935 1y ago
  I learned from an episode of "The Studio" that by "an eighth" you are likely referring to an eighth of an ounce is around 3.5 grams. Dude thought he got really mild shroom laced chocolates ("an eighth of a gram") and much hilarity ensued.
scellus 1y ago
Here's a rough breakdown from Claude: "[...] psilocybin converts to psilocin in the body at roughly a 1:1 ratio by active effect [...] Psilocybe cubensis (most common): Contains about 0.5-1.0% psilocybin by dry weight. Since psilocybin converts to psilocin in the body at roughly a 1:1 ratio by active effect, 30mg of psilocin would be equivalent to roughly 3-6 grams of dried P. cubensis. Psilocybe semilanceata (liberty caps): Much more potent at 1-2% psilocybin content, so you'd need only about 1.5-3 grams dried. Psilocybe azurescens: Even more potent at 1.5-2.5% psilocybin, requiring roughly 1-2 grams dried. Important caveats: - Individual mushrooms within the same species can vary by 3-5x in potency Growing conditions, harvesting time, and drying/storage methods all affect potency - The caps are typically more potent than stems - Fresh vs. dried makes a huge difference (fresh mushrooms are ~90% water)" Have to note that the paper is from 2016; for those really interested, it's good to read recent review papers.
- sampl3username 1y ago
  @grok is this true????
  - scellus 1y ago
    lol
- skeezyboy 1y ago
  there was a study recently showing no difference in caps v stems
locallost 1y ago
I don't know if that's true or false, but I would certainly not trust chatgpt blindly in this case.

Joel_Mckay 1y ago

That is the problem with clandestine pharmacy by Florida man, as people may get the wrong dose or a mixture of various other poisons like arsenic (see dark web article.) When ready, please talk with your doctor first. =3

awithrow 1y ago

A good ballpark for dried shrooms is roughly 1% psilocybin by weight of dried shroom, so about 3g. That said, it's going to vary a lot shroom to shroom, genetic to genetics, and species to species. Could be as high as 6g for more mild strains and as low a 1g for something like pan cyans.