4 ms·

I wonder how much of our diet contributes to these gut microbes?

by tmaly 1y ago

mtalantikite 1y ago
My immediate thought was "well, what do these bacteria feed on?".
- DebtDeflation 1y ago
  A quick Google search reveals these bacteria produce the imidazole propionate from histidine. Unfortunately, histidine is an essential amino acid (necessary for life and our bodies can't produce it so we need it in our diet).
  - Aurornis 1y ago
    The bacteria in your microbiome aren't a fixed quantity. Changing diet will change the microbiome over time. The researchers found that healthier diets and lifestyle were associated with lower levels of imidazole propionate. Trying to starve the bacteria of precursors isn't practical.
    - FollowingTheDao 1y ago
      > Trying to starve the bacteria of precursors isn't practical. Not starve them, but put them on a diet? Low B6 will lead to increased histidine by inhibiting Histidine decarboxylase. https://healthmatters.io/understand-blood-test-results/histidine-6 https://healthmatters.io/understand-blood-test-results/histi...
Aurornis 1y ago
Massively. Changing diet is about the only realistic way to elicit long-term changes in the microbiome. Even taking probiotics doesn't last very long. There's a lot of questionable microbiome science that hasn't been replicated. You can find a lot of studies that say something changes the microbiome, but it's almost always a single short-term observational study on a small group of people. Realistically, increasing vegetable intake and reducing processed food intake are the easiest knobs you can turn to adjust the microbiome. A lot of people reach for supplements or imagine extreme measures like fecal transplants, but the practical solution is to simply buy some snacking vegetables every time you go to the store and eat them throughout the day.
- TuringTourist 1y ago
  What is your definition of processed food? Are potatoes processed because they are cleaned? Is chicken breast processed because the chicken is plucked? Is vinegar processed because it has undergone a chemical transformation via fermentation? Are potato chips processed because they are sliced potatoes fried in oil? Are fried plantains processed because they are sliced plantains fried in oil? I do not mean to come across as antagonistic, I just haven't been able to find a line that everyone agrees with and felt it was useful to demonstrate that by asking a bunch of questions.
  - Diti 1y ago
    My personal definition is that if you can stack the food you buy, it has been processed. It’s a subjective definition, and there might be dozens of counterexamples, but it feels true to me.
    - bell-cot 1y ago
      So Pringles are, but regular potato chips aren't.
  - healthless 1y ago
    > What is your definition of processed food? Are potatoes processed because they are cleaned? Is chicken breast processed because the chicken is plucked? Is vinegar processed because it has undergone a chemical transformation via fermentation? Are potato chips processed because they are sliced potatoes fried in oil? Are fried plantains processed because they are sliced plantains fried in oil? In practice, for the vast majority, it doesn't matter where the line is drawn. Simply moving your diet as close as possible to unprocessed food (read: minimal steps between organism and ingestion) is the goal.
  - adammarples 1y ago
    Nobody seems to agree, but the best I've been able to find is that every step counts and the level of invasiveness does too. So a plucked chicken is one thing, but a plucked, chlorine rinsed, freeze dried, ground up, centrifuged, glued, rehydrated, salted, etc. is another
the8472 1y ago
https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1409119/full#h5 https://www.frontiersin.org/journals/endocrinology/articles/...

I wonder how much of our diet contributes to these gut microbes?

by tmaly 1y ago

I wonder how much of our diet contributes to these gut microbes?

mtalantikite 1y ago

My immediate thought was "well, what do these bacteria feed on?".

DebtDeflation 1y ago
A quick Google search reveals these bacteria produce the imidazole propionate from histidine. Unfortunately, histidine is an essential amino acid (necessary for life and our bodies can't produce it so we need it in our diet).
- Aurornis 1y ago
  The bacteria in your microbiome aren't a fixed quantity. Changing diet will change the microbiome over time. The researchers found that healthier diets and lifestyle were associated with lower levels of imidazole propionate. Trying to starve the bacteria of precursors isn't practical.
  - FollowingTheDao 1y ago
    > Trying to starve the bacteria of precursors isn't practical. Not starve them, but put them on a diet? Low B6 will lead to increased histidine by inhibiting Histidine decarboxylase. https://healthmatters.io/understand-blood-test-results/histidine-6 https://healthmatters.io/understand-blood-test-results/histi...

Aurornis 1y ago

Massively. Changing diet is about the only realistic way to elicit long-term changes in the microbiome. Even taking probiotics doesn't last very long. There's a lot of questionable microbiome science that hasn't been replicated. You can find a lot of studies that say something changes the microbiome, but it's almost always a single short-term observational study on a small group of people. Realistically, increasing vegetable intake and reducing processed food intake are the easiest knobs you can turn to adjust the microbiome. A lot of people reach for supplements or imagine extreme measures like fecal transplants, but the practical solution is to simply buy some snacking vegetables every time you go to the store and eat them throughout the day.

TuringTourist 1y ago
What is your definition of processed food? Are potatoes processed because they are cleaned? Is chicken breast processed because the chicken is plucked? Is vinegar processed because it has undergone a chemical transformation via fermentation? Are potato chips processed because they are sliced potatoes fried in oil? Are fried plantains processed because they are sliced plantains fried in oil? I do not mean to come across as antagonistic, I just haven't been able to find a line that everyone agrees with and felt it was useful to demonstrate that by asking a bunch of questions.
- Diti 1y ago
  My personal definition is that if you can stack the food you buy, it has been processed. It’s a subjective definition, and there might be dozens of counterexamples, but it feels true to me.
  - bell-cot 1y ago
    So Pringles are, but regular potato chips aren't.
- healthless 1y ago
  > What is your definition of processed food? Are potatoes processed because they are cleaned? Is chicken breast processed because the chicken is plucked? Is vinegar processed because it has undergone a chemical transformation via fermentation? Are potato chips processed because they are sliced potatoes fried in oil? Are fried plantains processed because they are sliced plantains fried in oil? In practice, for the vast majority, it doesn't matter where the line is drawn. Simply moving your diet as close as possible to unprocessed food (read: minimal steps between organism and ingestion) is the goal.
- adammarples 1y ago
  Nobody seems to agree, but the best I've been able to find is that every step counts and the level of invasiveness does too. So a plucked chicken is one thing, but a plucked, chlorine rinsed, freeze dried, ground up, centrifuged, glued, rehydrated, salted, etc. is another

the8472 1y ago

https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2025.1409119/full#h5 https://www.frontiersin.org/journals/endocrinology/articles/...