I have found the same thing, but my experience (YMMV; not recommended that you take my advice!) is that a one week break almost entirely resets it. I now take

I have found the same thing, but my experience (YMMV; not recommended that you take my advice!) is that a one week break almost entirely resets it. I now take a one week break every few months and have not noticed any decline in effects over time. My suggestion would be to find an endocrinologist that specialises in obesity and these weight loss drugs. They will have dealt with patients who have experienced tolerance and have developed ways to work around it from real life experience. Obviously well-studied protocols with evidence would be preferable, but with how new these drugs are there hasn't been long enough to collect it yet.