4 ms·

I wouldn’t say unnoticeable, but rather a trade-off that’s fine. My stomach is definitely more sensitive, can’t handle coffee in the morning anymore, etc. It pr

I wouldn’t say unnoticeable, but rather a trade-off that’s fine. My stomach is definitely more sensitive, can’t handle coffee in the morning anymore, etc. It probably depends on the person.

wincy 1y ago
I can tolerate tea quite well. Unseeetened iced tea by the gallon, specifically.
- esperent 1y ago
  I'm not on any medications, and I've never been able to handle tea in the morning. Green, black, iced, hot, matcha. It always makes me feel nauseated unless I've eaten breakfast first. I always drink black coffee though, without problems.
  - data_marsupial 1y ago
    I am similar. Green tea always makes me feel nauseous on an empty stomach. Tea with milk is normally ok.
    - oger 1y ago
      That's why the Brits are having it ;-)
  - throaway955 1y ago
    This is due to the high concentration of tannin in the tea. It causes stomach problems if you dont have protein in your belly already.
    - gbcbooks 1y ago
      [dead]
Auracle 1y ago
Huh. I’m at a healthy weight but I’m taking retatrutide for IBS and it’s working wonders. Very low dose, though. I originally tried it with semaglutide before the weight loss craze kicked off and the first few days of the week were worse and the latter half of the week was better, so that didn’t make sense for me to stay on.
- solumunus 1y ago
  With all of these long acting GLP's you will get a much smoother experience dosing them 2-3 times/week.
  - malfist 1y ago
    Maybe in the first few weeks, but their half-life is 7 days. You're not doing much besides making a hassle for yourself if your doing that after the first couple of weeks
    - solumunus 1y ago
      The amount of "time on" is completely irrelevant. You will reduce peaks and troughs by injecting > once/week, this is a fact.
  - loeg 1y ago
    Yeah, I guess it's worth adding my relatively moderate side effect experience has been dosing 2-3x/week the whole time.
- pugz 1y ago
  Can you say more about retatrutide for IBS? My IBS is debilitating to the point where I usually refuse to eat food on week-long work trips, because the unplanned emergency toilet trips wreak havoc with my schedule and ability to sit in meetings all day. I'd never heard there was a solution to it.
  - Auracle 1y ago
    Sure, and I totally get your issues. I was a damned wedding photographer and I'd only eat towards the very end of the night, and still had a few iffy days. As I stated, I originally tried semaglutide with no luck. I didn't try tirzepatide. I've been taking a very low dose of retatrutide - about .5mg twice a week. It seemed to be waning in effectiveness a bit so I upped the dose to 2mg/week for now. It's a night and day difference. Most days I go to the bathroom maybe two times, as opposed to the maybe 5-10 times I would need to unmedicated. To be clear, this isn't an approved use of the medications (and retatrutide isn't approved at all yet, though it pretty clearly will be). However, they slow down gut motility - and as a bonus for your refusing to eat during week-long work trips, they'd probably at least help with that too, in terms of hunger.

I wouldn’t say unnoticeable, but rather a trade-off that’s fine. My stomach is definitely more sensitive, can’t handle coffee in the morning anymore, etc. It probably depends on the person.

wincy 1y ago

I can tolerate tea quite well. Unseeetened iced tea by the gallon, specifically.

esperent 1y ago
I'm not on any medications, and I've never been able to handle tea in the morning. Green, black, iced, hot, matcha. It always makes me feel nauseated unless I've eaten breakfast first. I always drink black coffee though, without problems.
- data_marsupial 1y ago
  I am similar. Green tea always makes me feel nauseous on an empty stomach. Tea with milk is normally ok.
  - oger 1y ago
    That's why the Brits are having it ;-)
- throaway955 1y ago
  This is due to the high concentration of tannin in the tea. It causes stomach problems if you dont have protein in your belly already.
  - gbcbooks 1y ago
    [dead]

Auracle 1y ago

Huh. I’m at a healthy weight but I’m taking retatrutide for IBS and it’s working wonders. Very low dose, though. I originally tried it with semaglutide before the weight loss craze kicked off and the first few days of the week were worse and the latter half of the week was better, so that didn’t make sense for me to stay on.

solumunus 1y ago
With all of these long acting GLP's you will get a much smoother experience dosing them 2-3 times/week.
- malfist 1y ago
  Maybe in the first few weeks, but their half-life is 7 days. You're not doing much besides making a hassle for yourself if your doing that after the first couple of weeks
  - solumunus 1y ago
    The amount of "time on" is completely irrelevant. You will reduce peaks and troughs by injecting > once/week, this is a fact.
- loeg 1y ago
  Yeah, I guess it's worth adding my relatively moderate side effect experience has been dosing 2-3x/week the whole time.
pugz 1y ago
Can you say more about retatrutide for IBS? My IBS is debilitating to the point where I usually refuse to eat food on week-long work trips, because the unplanned emergency toilet trips wreak havoc with my schedule and ability to sit in meetings all day. I'd never heard there was a solution to it.
- Auracle 1y ago
  Sure, and I totally get your issues. I was a damned wedding photographer and I'd only eat towards the very end of the night, and still had a few iffy days. As I stated, I originally tried semaglutide with no luck. I didn't try tirzepatide. I've been taking a very low dose of retatrutide - about .5mg twice a week. It seemed to be waning in effectiveness a bit so I upped the dose to 2mg/week for now. It's a night and day difference. Most days I go to the bathroom maybe two times, as opposed to the maybe 5-10 times I would need to unmedicated. To be clear, this isn't an approved use of the medications (and retatrutide isn't approved at all yet, though it pretty clearly will be). However, they slow down gut motility - and as a bonus for your refusing to eat during week-long work trips, they'd probably at least help with that too, in terms of hunger.