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According to all the studies, this is absolutely the worst thing that you can do. GLP-1s are revolutionary, but when you go on them, you should intend to stay o

According to all the studies, this is absolutely the worst thing that you can do. GLP-1s are revolutionary, but when you go on them, you should intend to stay on them for life. When patients first go on them, they lose both muscle and fat, and when they go off them, they regain just fat, and in many cases they're in a worse situation than they would be if they hadn't gone on them in the first place. Letting your weight fluctuate up and down in giant swings is, in many ways, harder on the body than just staying at a steady weight, even if it's overweight.

nwienert 1y ago
This is nearly perfectly wrong. There’s nothing in these drugs that makes you lose more muscle than fat, you don’t lose any more muscle than if you do a regular diet, not even slightly. Second, the drugs don’t do anything to cause you to gain back mostly fat, and people going off them have more success, not less, than your average person who loses weight rapidly whether through diet or other means. The average person who is 50lbs overweight because they gained 5lbs a year for a decade will lose all of that weight within 6 months with nearly entirely positive side effects, and if they stop taking it, will regain a bit less than they did before, meaning it would take another decade to get back to where they were. That is unequivocally a huge net positive. It’s not like Testosterone which does have dramatic negative effects when taken long term and can cause dependency. It also happens to be extremely effective at reducing bad habits, and yes those habit changes persist after quitting - not perfectly, but surprisingly so. This even works for smoking, drinking, and gambling.
alvah 1y ago
GLP-1 definitely doesn’t prevent you increasing your percentage of total calories from protein, and doing regular resistance exercise. That was the advice from my doctor, and while I’m only 2 months in, weekly scans have not yet shown any significant decrease in lean mass. I don’t see any reason why they would, as long as I continue eating protein and lifting heavy things.

nwienert 1y ago

This is nearly perfectly wrong. There’s nothing in these drugs that makes you lose more muscle than fat, you don’t lose any more muscle than if you do a regular diet, not even slightly. Second, the drugs don’t do anything to cause you to gain back mostly fat, and people going off them have more success, not less, than your average person who loses weight rapidly whether through diet or other means. The average person who is 50lbs overweight because they gained 5lbs a year for a decade will lose all of that weight within 6 months with nearly entirely positive side effects, and if they stop taking it, will regain a bit less than they did before, meaning it would take another decade to get back to where they were. That is unequivocally a huge net positive. It’s not like Testosterone which does have dramatic negative effects when taken long term and can cause dependency. It also happens to be extremely effective at reducing bad habits, and yes those habit changes persist after quitting - not perfectly, but surprisingly so. This even works for smoking, drinking, and gambling.

alvah 1y ago

GLP-1 definitely doesn’t prevent you increasing your percentage of total calories from protein, and doing regular resistance exercise. That was the advice from my doctor, and while I’m only 2 months in, weekly scans have not yet shown any significant decrease in lean mass. I don’t see any reason why they would, as long as I continue eating protein and lifting heavy things.