16 ms·

They aren't even that awful in maintenance -- just expensive. The unpleasant part is when you're increasing the dose. After a while at the same dose, it's mor

by loeg 1y ago

They aren't even that awful in maintenance -- just expensive. The unpleasant part is when you're increasing the dose. After a while at the same dose, it's more or less unnoticeable IMO.

gregw134 1y ago
Unnoticable meaning doesn't have any effect at all, or just no bad side effects?
- throwawaysleep 1y ago
  As in I cannot identify anything wrong with me most of the time while on them.
- loeg 1y ago
  Just in terms of bad side effects. Hunger was still suppressed. (Might be worse on the higher doses, I'm not on a very high dose.)
  - PeterStuer 1y ago
    Why would that be a 'bad' side effect? Isn't that the whole point of the medication?
    - coldtea 1y ago
      Parent is not saying hunger supression is a bad side effect, they just clarify that the difference in noticabeality talked about a few comments up refers to the bad ones - but the good one's remain the same.
- craz8 1y ago
  I have 2 measurable ones on Zepbound. My lowest sleeping heart rate is now at least 10 beats higher than before starting (it comes down during the week to about 10 over) The night after taking the injection my sleep is crap, and the heart rate is 5+ higher again I have lost 20lbs since mid March with no real effort, and we’re about to do some blood tests for specific cholesterol numbers, which was one of the reasons to try this out.
- wincy 1y ago
  I’ve been on 15mg (the highest dose) of Zepbound for the past six months. As of right this second I’ve lost 74 pounds since September 2024 when I switched to Zepbound after having a terrible experience with Ozempic/Wegovy and gaining from 260-308. I notice no ill effects, I just had my three month checkup with the doctor and he thinks I’m good on maintenance mode at max dose, I’ve still got about 34 pounds as my total weight loss goal. Really an ideal case. For my wife on the other hand she just has constant diarrhea which she blames on the drug, and is only on 5mg. She also gets headaches from the medicine. She’s lost only 20 pounds, even though she needs to lose another 120 or so to be “healthy weight”. However, before she started taking Zepbound she was only able to walk a few hundred feet at a time, because her back hurt so terribly. The anti inflammatory “side effects” she’s experiencing have massively improved her quality of life, even without huge amounts of weight loss.
  - stavros 1y ago
    I'm on 2.5mg and I just got sulfur burps, which, to me, is the worst side-effect of the lot. I've also gotten terrible diarrhea previously, even on the lowest dose, I've started and stopped it around five times. Hopefully fifth time's the charm, but yes, side-effects very much depend on the person. I have friends on 10mg and 15mg and they're fine.
  - malfist 1y ago
    I'm sorry to hear about your wife's issues with it. My experience was completely the opposite. Since glp-1s slow gastric emptying they've completely ameliorated my IBS-D. It's been marvelous
- potato3732842 1y ago
  Below the baseline of individual variance. Like if your stomach really hated taco bell and you start taking a pill and now you get the same effect from artificial sweeteners you don't care because you're still within what's normal. That's the level of side effects these things have.
stingraycharles 1y ago
I wouldn’t say unnoticeable, but rather a trade-off that’s fine. My stomach is definitely more sensitive, can’t handle coffee in the morning anymore, etc. It probably depends on the person.
- wincy 1y ago
  I can tolerate tea quite well. Unseeetened iced tea by the gallon, specifically.
  - esperent 1y ago
    I'm not on any medications, and I've never been able to handle tea in the morning. Green, black, iced, hot, matcha. It always makes me feel nauseated unless I've eaten breakfast first. I always drink black coffee though, without problems.
    - data_marsupial 1y ago
      I am similar. Green tea always makes me feel nauseous on an empty stomach. Tea with milk is normally ok.
      - oger 1y ago
        That's why the Brits are having it ;-)
    - throaway955 1y ago
      This is due to the high concentration of tannin in the tea. It causes stomach problems if you dont have protein in your belly already.
      - gbcbooks 1y ago
        [dead]
- Auracle 1y ago

by loeg 1y ago

They aren't even that awful in maintenance -- just expensive. The unpleasant part is when you're increasing the dose. After a while at the same dose, it's more or less unnoticeable IMO.

gregw134 1y ago

Unnoticable meaning doesn't have any effect at all, or just no bad side effects?

throwawaysleep 1y ago
As in I cannot identify anything wrong with me most of the time while on them.
loeg 1y ago
Just in terms of bad side effects. Hunger was still suppressed. (Might be worse on the higher doses, I'm not on a very high dose.)
- PeterStuer 1y ago
  Why would that be a 'bad' side effect? Isn't that the whole point of the medication?
  - coldtea 1y ago
    Parent is not saying hunger supression is a bad side effect, they just clarify that the difference in noticabeality talked about a few comments up refers to the bad ones - but the good one's remain the same.
craz8 1y ago
I have 2 measurable ones on Zepbound. My lowest sleeping heart rate is now at least 10 beats higher than before starting (it comes down during the week to about 10 over) The night after taking the injection my sleep is crap, and the heart rate is 5+ higher again I have lost 20lbs since mid March with no real effort, and we’re about to do some blood tests for specific cholesterol numbers, which was one of the reasons to try this out.
wincy 1y ago
I’ve been on 15mg (the highest dose) of Zepbound for the past six months. As of right this second I’ve lost 74 pounds since September 2024 when I switched to Zepbound after having a terrible experience with Ozempic/Wegovy and gaining from 260-308. I notice no ill effects, I just had my three month checkup with the doctor and he thinks I’m good on maintenance mode at max dose, I’ve still got about 34 pounds as my total weight loss goal. Really an ideal case. For my wife on the other hand she just has constant diarrhea which she blames on the drug, and is only on 5mg. She also gets headaches from the medicine. She’s lost only 20 pounds, even though she needs to lose another 120 or so to be “healthy weight”. However, before she started taking Zepbound she was only able to walk a few hundred feet at a time, because her back hurt so terribly. The anti inflammatory “side effects” she’s experiencing have massively improved her quality of life, even without huge amounts of weight loss.
- stavros 1y ago
  I'm on 2.5mg and I just got sulfur burps, which, to me, is the worst side-effect of the lot. I've also gotten terrible diarrhea previously, even on the lowest dose, I've started and stopped it around five times. Hopefully fifth time's the charm, but yes, side-effects very much depend on the person. I have friends on 10mg and 15mg and they're fine.
- malfist 1y ago
  I'm sorry to hear about your wife's issues with it. My experience was completely the opposite. Since glp-1s slow gastric emptying they've completely ameliorated my IBS-D. It's been marvelous
potato3732842 1y ago
Below the baseline of individual variance. Like if your stomach really hated taco bell and you start taking a pill and now you get the same effect from artificial sweeteners you don't care because you're still within what's normal. That's the level of side effects these things have.

stingraycharles 1y ago

I wouldn’t say unnoticeable, but rather a trade-off that’s fine. My stomach is definitely more sensitive, can’t handle coffee in the morning anymore, etc. It probably depends on the person.

wincy 1y ago
I can tolerate tea quite well. Unseeetened iced tea by the gallon, specifically.
- esperent 1y ago
  I'm not on any medications, and I've never been able to handle tea in the morning. Green, black, iced, hot, matcha. It always makes me feel nauseated unless I've eaten breakfast first. I always drink black coffee though, without problems.
  - data_marsupial 1y ago
    I am similar. Green tea always makes me feel nauseous on an empty stomach. Tea with milk is normally ok.
    - oger 1y ago
      That's why the Brits are having it ;-)
  - throaway955 1y ago
    This is due to the high concentration of tannin in the tea. It causes stomach problems if you dont have protein in your belly already.
    - gbcbooks 1y ago
      [dead]
Auracle 1y ago