5 ms·

A once-weekly subcutaneous injection is not a big deal for most people I think, outside of those who are very afraid of needles. It's a tiny needle and you don'

A once-weekly subcutaneous injection is not a big deal for most people I think, outside of those who are very afraid of needles. It's a tiny needle and you don't even feel it. I've given injections to people who are afraid of needles, and they sometimes close their eyes in fear and are begging me to "just get it over with" without even realizing that I'm already done. Anyway, all this to say that outside of needle-phobic people I think the annoyance of the injections is probably not the reason people stop taking GLP-1 agonists.

cjbgkagh 1y ago
You don’t feel it most of the time, it’s actually random with the sparse placement of nerves. Maybe 1 in 5 still sting a bit.
loeg 1y ago
> It's a tiny needle and you don't even feel it. I'll add that while it isn't a big deal, I definitely feel the needle; sometimes worse than others. (I'm using 8mm 30 gauge needles.)
- swat535 1y ago
  You have to inject it correctly, it needs to be injected in the fat and with the right angle. If you have very little body fat, your glutes are probably a better place. Source: I take HCG and have to use injection 2x a week. 27G is my favorite.. https://medneedles.ca/products/1ml-27g-x-1-2-sol-care%E2%84%A2-tb-safety-syringe-with-fixed-needle-100-per-box https://medneedles.ca/products/1ml-27g-x-1-2-sol-care%E2%84%...
  - cjbgkagh 1y ago
    It’s mostly random and some people do feel it more than others. It’s a rapidly absorbed peptide suspended in water, it could even be used with a transdermal patch, so it doesn’t matter that much where it gets in or how deep. Best to avoid painful areas though.
  - loeg 1y ago
    It is correct (belly). :-) I think I remember it being less painful when I was fatter? The 30G/8mm needles I'm using are smaller than your 27G/13mm needles in both dimensions; should be better, if anything. Again, it's not a big deal, but I feel it.
randallsquared 1y ago
As someone who is mildly needle-phobic, I'll agree it's no big deal, but you definitely can feel it, and if you hit a blood vessel by accident, there's a (mostly painless) bump and 2-3 week bruise at the injection site, which might be a major issue for some.
- sroussey 1y ago
  Be sure to pull back on the plunger and ensure there the needle is not in a blood vessel (pulling back will draw blood into the thing and you will see). You do not want the drug meant to subcutaneous to go into the blood steam. This is true for GPL-1s (all peptides for that matter), as well as insulin, and definitely mRNA vaccines.
  - abruzzi 1y ago
    Mounjaro uses a single use fully autometed injector--clean your skin, remove the cap, press the injector against your skin, then press a button. A springloaded needle penetrates you skin and a spring loaded plunger injects the medicine. You have no way to pull backthe plunger to see if you are in a vein/artery. I've never used Ozempic, but my understanding was it used a device similar to insulin pens--dial you dosage, attach needle, insert needle, press at the base of the pen to inject the selected amount. Also no way to pull back to see if you hit a vein/artery.
    - randallsquared 1y ago
      This is right. It's all or nothing, and there's no "pull back" functionality.
      - sroussey 1y ago
        Only on the autoinjectors. Not true with the vial and insulin needles.
    - wormius 1y ago
      Yeah, both Ozempic and Trulicity have automated systems like this, just press a button and pop. Is there even a way to hit a vein? The needle is not very deep (it's subcutaneous, just barely under the skin). And it's the stomach, which AFAIK, doesn't have a lot of exposed veins? Either way super simple and quick. Fairly painless. I had a weird rash one time, but apart from that a total of about 15 injections haven't had any issues on either Ozempic or Trulicity in terms of injections. Others may have difficulties, but it's been super easy IMO.
wonderwonder 1y ago
I take 18 shots a week - Big fan of better living through chemistry I don't even notice the SubQ shots anymore. The only annoying part is I have to lean forward to find enough belly fat when I shoot there. Still not a huge fan of the IM injections into my legs but we all suffer for our art.

cjbgkagh 1y ago

You don’t feel it most of the time, it’s actually random with the sparse placement of nerves. Maybe 1 in 5 still sting a bit.

loeg 1y ago

> It's a tiny needle and you don't even feel it. I'll add that while it isn't a big deal, I definitely feel the needle; sometimes worse than others. (I'm using 8mm 30 gauge needles.)

swat535 1y ago
You have to inject it correctly, it needs to be injected in the fat and with the right angle. If you have very little body fat, your glutes are probably a better place. Source: I take HCG and have to use injection 2x a week. 27G is my favorite.. https://medneedles.ca/products/1ml-27g-x-1-2-sol-care%E2%84%A2-tb-safety-syringe-with-fixed-needle-100-per-box https://medneedles.ca/products/1ml-27g-x-1-2-sol-care%E2%84%...
- cjbgkagh 1y ago
  It’s mostly random and some people do feel it more than others. It’s a rapidly absorbed peptide suspended in water, it could even be used with a transdermal patch, so it doesn’t matter that much where it gets in or how deep. Best to avoid painful areas though.
- loeg 1y ago
  It is correct (belly). :-) I think I remember it being less painful when I was fatter? The 30G/8mm needles I'm using are smaller than your 27G/13mm needles in both dimensions; should be better, if anything. Again, it's not a big deal, but I feel it.

randallsquared 1y ago

As someone who is mildly needle-phobic, I'll agree it's no big deal, but you definitely can feel it, and if you hit a blood vessel by accident, there's a (mostly painless) bump and 2-3 week bruise at the injection site, which might be a major issue for some.

sroussey 1y ago
Be sure to pull back on the plunger and ensure there the needle is not in a blood vessel (pulling back will draw blood into the thing and you will see). You do not want the drug meant to subcutaneous to go into the blood steam. This is true for GPL-1s (all peptides for that matter), as well as insulin, and definitely mRNA vaccines.
- abruzzi 1y ago
  Mounjaro uses a single use fully autometed injector--clean your skin, remove the cap, press the injector against your skin, then press a button. A springloaded needle penetrates you skin and a spring loaded plunger injects the medicine. You have no way to pull backthe plunger to see if you are in a vein/artery. I've never used Ozempic, but my understanding was it used a device similar to insulin pens--dial you dosage, attach needle, insert needle, press at the base of the pen to inject the selected amount. Also no way to pull back to see if you hit a vein/artery.
  - randallsquared 1y ago
    This is right. It's all or nothing, and there's no "pull back" functionality.
    - sroussey 1y ago
      Only on the autoinjectors. Not true with the vial and insulin needles.
  - wormius 1y ago
    Yeah, both Ozempic and Trulicity have automated systems like this, just press a button and pop. Is there even a way to hit a vein? The needle is not very deep (it's subcutaneous, just barely under the skin). And it's the stomach, which AFAIK, doesn't have a lot of exposed veins? Either way super simple and quick. Fairly painless. I had a weird rash one time, but apart from that a total of about 15 injections haven't had any issues on either Ozempic or Trulicity in terms of injections. Others may have difficulties, but it's been super easy IMO.

wonderwonder 1y ago

I take 18 shots a week - Big fan of better living through chemistry I don't even notice the SubQ shots anymore. The only annoying part is I have to lean forward to find enough belly fat when I shoot there. Still not a huge fan of the IM injections into my legs but we all suffer for our art.