3 ms·

so surreal reading comments... a month after non-stop threads about glp causing a billion issues, everyone is talking about how wonderful they are again. human

so surreal reading comments... a month after non-stop threads about glp causing a billion issues, everyone is talking about how wonderful they are again. humanity

brokensegue 1y ago
billion issues? i saw some reporting on rare cases of blindness. what else?
- paulpauper 1y ago
  1-2 years ago there was considerable skepticism about "taking the easy way out" or unforeseen risks like like with Fenfluramine/phentermine. Now sentiment has changed given that more people realize these drugs are safe and effective.
- octo888 1y ago
  Pancreas issues and hair loss IIRC?
  - adgjlsfhk1 1y ago
    Hair loss is 1. Exactly the type of "side effect" that people will report because they lost hair (because lots of people experience hair loss whether they are on a GLP1 or not) 2. A fairly minor side effect that wouldn't be a strong reason to not prescribe. Pancreas issues were worried about, but those worries (so far) appear to be unfounded. https://pmc.ncbi.nlm.nih.gov/articles/PMC6382780/ https://pmc.ncbi.nlm.nih.gov/articles/PMC6382780/ is a meta-analysis of 12 studies (36k patients) over 2 years that showed no evidence of increased pacreatic issues, and https://pubmed.ncbi.nlm.nih.gov/38175642/ https://pubmed.ncbi.nlm.nih.gov/38175642/ is a 7 year analysis of ~33k patients that also shows no increase in issues.
nwienert 1y ago
It's a once in a generation drug with less side effects than most OTC, likely net positive even for healthy weight people. I'd bet within the decade it'll be approved for a whole basket of other benefits - at the least a whole array of immune system disfunctions and a cure-all for addiction. Likely protective of a wide array of internal organs, likely life extending.
saturneria 1y ago
What is well studied and has a billion issues is obesity. Imagine that, people make up bullshit that isn't grounded in reality. Who would have thought!
Gothmog69 1y ago
That's interesting I keep reading about a billion issues glp1 help like addiction, alzheimers and more

so surreal reading comments... a month after non-stop threads about glp causing a billion issues, everyone is talking about how wonderful they are again. humanity

brokensegue 1y ago

billion issues? i saw some reporting on rare cases of blindness. what else?

paulpauper 1y ago
1-2 years ago there was considerable skepticism about "taking the easy way out" or unforeseen risks like like with Fenfluramine/phentermine. Now sentiment has changed given that more people realize these drugs are safe and effective.
octo888 1y ago
Pancreas issues and hair loss IIRC?
- adgjlsfhk1 1y ago
  Hair loss is 1. Exactly the type of "side effect" that people will report because they lost hair (because lots of people experience hair loss whether they are on a GLP1 or not) 2. A fairly minor side effect that wouldn't be a strong reason to not prescribe. Pancreas issues were worried about, but those worries (so far) appear to be unfounded. https://pmc.ncbi.nlm.nih.gov/articles/PMC6382780/ https://pmc.ncbi.nlm.nih.gov/articles/PMC6382780/ is a meta-analysis of 12 studies (36k patients) over 2 years that showed no evidence of increased pacreatic issues, and https://pubmed.ncbi.nlm.nih.gov/38175642/ https://pubmed.ncbi.nlm.nih.gov/38175642/ is a 7 year analysis of ~33k patients that also shows no increase in issues.

nwienert 1y ago

It's a once in a generation drug with less side effects than most OTC, likely net positive even for healthy weight people. I'd bet within the decade it'll be approved for a whole basket of other benefits - at the least a whole array of immune system disfunctions and a cure-all for addiction. Likely protective of a wide array of internal organs, likely life extending.

saturneria 1y ago

What is well studied and has a billion issues is obesity. Imagine that, people make up bullshit that isn't grounded in reality. Who would have thought!

Gothmog69 1y ago

That's interesting I keep reading about a billion issues glp1 help like addiction, alzheimers and more