3 ms·
Tell me you never studied basic med chem or pharmacology without telling me... You can't use animal models for dose, you have to convert to hED (Human-Equivale
by gavinray 1y ago
Tell me you never studied basic med chem or pharmacology without telling me...
You can't use animal models for dose, you have to convert to hED (Human-Equivalent Dosage). You can estimate this generally with allometric scaling:
https://drughunter.com/practical-pk-calculators https://drughunter.com/practical-pk-calculators
Also, animal physiology varies.
Beta-adrenergic agonists like clenbuterol make mice wildly muscular, which unfortunately is not the case in humans, for example.