4 ms·

> being able to "shut it off" was a good thing - you can turn an IV off, but once you inhale, you're on your own How does it work? Is the half-life of it short

> being able to "shut it off" was a good thing - you can turn an IV off, but once you inhale, you're on your own How does it work? Is the half-life of it shorter when administered IV?

sneak 1y ago
Only a little. Not enough to serve as an escape hatch. It depends on the infusion rate, of course, but you’re talking a difference of maybe 15-20 minutes.
gavinray 1y ago
I had a Ketamine infusion done at a clinic in Miami. It was $600 (discounted) for the first infusion. You go through a pre-evaluation with the doctor, where they determine a dosage for you based on prior experience and bodyweight. My clinic also offered to co-administer IV benzos to prevent panic attacks or negative experiences, which was a HUGE plus for me. During the experience you're given a button, which you can press to call them and have the drip turned off or turned down. If it wasn't so expensive or covered by my insurance, I would've certainly repeated it. Highly recommend.
- notpushkin 1y ago
  Very interesting, thanks for sharing! I’ve read that you can get your hands on a solution for Ketamine injections (or, if you have pure Ketamine, just prepare one yourself). Most go for intra-muscular injections instead (~70% bioavailability compared to IV, still great compared to ~10% when snorted). The reason they give is, when administered IV it wears off way too quickly – I guess drip solves this one! This is, of course, way more risky and pretty much illegal I guess, but it should probably be cheaper?
  - gavinray 1y ago
    It'll be significantly cheaper, and assuming you purchase the Ketamine from a reputable source/vendor and use a test kit on it, the risk is comparatively "minimal". Not necessarily "condoning" the behavior, so much as sharing harm-minimization info here: For safe/sterile injection, you need three things, all cheaply + easily available on the internet. 1) Bacteriostatic water - https://www.amazon.com/bacteriostatic-water/s?k=bacteriostatic+water https://www.amazon.com/bacteriostatic-water/s?k=bacteriostat... 2) Sealed, sterile vials for preparation of the solution - https://www.amazon.com/Sterile-Vial/s?k=Sterile+Vial https://www.amazon.com/Sterile-Vial/s?k=Sterile+Vial 3) Insulin syringes. 29g 0.5" work well. https://www.amazon.com/s?k=29g+1cc+1%2F2+inch+insulin+syringes&crid=1G75I7Y64D8WD&sprefix=29g+1%2F2+inch+in%2Caps%2C137&ref=nb_sb_ss_p13n-expert-pd-ops-ranker_1_15 https://www.amazon.com/s?k=29g+1cc+1%2F2+inch+insulin+syring... See my comment in this thread about IM administration of 4-AcO-DMT for more info: https://news.ycombinator.com/item?id=44535690 https://news.ycombinator.com/item?id=44535690
- reverendjames 1y ago
  Ketamine is dumb. Nothing like a psychedelic drug such as LSD.

> being able to "shut it off" was a good thing - you can turn an IV off, but once you inhale, you're on your own How does it work? Is the half-life of it shorter when administered IV?

sneak 1y ago

Only a little. Not enough to serve as an escape hatch. It depends on the infusion rate, of course, but you’re talking a difference of maybe 15-20 minutes.

gavinray 1y ago

I had a Ketamine infusion done at a clinic in Miami. It was $600 (discounted) for the first infusion. You go through a pre-evaluation with the doctor, where they determine a dosage for you based on prior experience and bodyweight. My clinic also offered to co-administer IV benzos to prevent panic attacks or negative experiences, which was a HUGE plus for me. During the experience you're given a button, which you can press to call them and have the drip turned off or turned down. If it wasn't so expensive or covered by my insurance, I would've certainly repeated it. Highly recommend.

notpushkin 1y ago
Very interesting, thanks for sharing! I’ve read that you can get your hands on a solution for Ketamine injections (or, if you have pure Ketamine, just prepare one yourself). Most go for intra-muscular injections instead (~70% bioavailability compared to IV, still great compared to ~10% when snorted). The reason they give is, when administered IV it wears off way too quickly – I guess drip solves this one! This is, of course, way more risky and pretty much illegal I guess, but it should probably be cheaper?
- gavinray 1y ago
  It'll be significantly cheaper, and assuming you purchase the Ketamine from a reputable source/vendor and use a test kit on it, the risk is comparatively "minimal". Not necessarily "condoning" the behavior, so much as sharing harm-minimization info here: For safe/sterile injection, you need three things, all cheaply + easily available on the internet. 1) Bacteriostatic water - https://www.amazon.com/bacteriostatic-water/s?k=bacteriostatic+water https://www.amazon.com/bacteriostatic-water/s?k=bacteriostat... 2) Sealed, sterile vials for preparation of the solution - https://www.amazon.com/Sterile-Vial/s?k=Sterile+Vial https://www.amazon.com/Sterile-Vial/s?k=Sterile+Vial 3) Insulin syringes. 29g 0.5" work well. https://www.amazon.com/s?k=29g+1cc+1%2F2+inch+insulin+syringes&crid=1G75I7Y64D8WD&sprefix=29g+1%2F2+inch+in%2Caps%2C137&ref=nb_sb_ss_p13n-expert-pd-ops-ranker_1_15 https://www.amazon.com/s?k=29g+1cc+1%2F2+inch+insulin+syring... See my comment in this thread about IM administration of 4-AcO-DMT for more info: https://news.ycombinator.com/item?id=44535690 https://news.ycombinator.com/item?id=44535690
reverendjames 1y ago
Ketamine is dumb. Nothing like a psychedelic drug such as LSD.