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Aging well requires a both biological and lifestyle interventions. One company called Nuraxi [1] is geared precisely to support that, They aim at studying the s

Aging well requires a both biological and lifestyle interventions. One company called Nuraxi [1] is geared precisely to support that, They aim at studying the super-agers in the Sardinia "blue zone", and build digital twins (for the rest of us) on which simulate all-round interventions based on the insights from super-agers. Sounds like a promising way to get personalised longevity recipes. [1] https://www.nuraxi.ai https://www.nuraxi.ai

morleytj 1y ago
I was under the impression that the majority of recent analysis pointed to the interpretation that most of the claimed blue zones were primarily marked as such due to poor record keeping rather than true super ager status. Is Sardinia an exception to this?
amy_petrik 1y ago
> build digital twins (for the rest of us) on which simulate all-round interventions based Digital twins, what a freaking crock. Imagine claiming to simulate the biochemical pathways of a trillion cells and 3 billion basepairs and a gorillion chemicals and sequestration zones. Least they could do is take a little tissue and screw around with a patient-derived organoid. If someone made a digital twin that worked proper they'd be making a killing in pharma trials and drug development
- rippeltippel 1y ago
  My understanding of a "digital twin" is not as something that aims at simulating human biochemistry. It's rather a model that captures specific aspects, not necessarily biological ones. There's a good amount of literature on that subject, e.g. interesting meta-studies studies as [1] and [2], and more [3]. [1] https://ieeexplore.ieee.org/abstract/document/10379674 https://ieeexplore.ieee.org/abstract/document/10379674 [2] https://www.nature.com/articles/s41746-024-01073-0 https://www.nature.com/articles/s41746-024-01073-0 [3] https://scholar.google.com/scholar?q=digital+twin+health&hl=en&as_sdt=0,5 https://scholar.google.com/scholar?q=digital+twin+health&hl=...

morleytj 1y ago

I was under the impression that the majority of recent analysis pointed to the interpretation that most of the claimed blue zones were primarily marked as such due to poor record keeping rather than true super ager status. Is Sardinia an exception to this?

amy_petrik 1y ago

> build digital twins (for the rest of us) on which simulate all-round interventions based Digital twins, what a freaking crock. Imagine claiming to simulate the biochemical pathways of a trillion cells and 3 billion basepairs and a gorillion chemicals and sequestration zones. Least they could do is take a little tissue and screw around with a patient-derived organoid. If someone made a digital twin that worked proper they'd be making a killing in pharma trials and drug development

rippeltippel 1y ago
My understanding of a "digital twin" is not as something that aims at simulating human biochemistry. It's rather a model that captures specific aspects, not necessarily biological ones. There's a good amount of literature on that subject, e.g. interesting meta-studies studies as [1] and [2], and more [3]. [1] https://ieeexplore.ieee.org/abstract/document/10379674 https://ieeexplore.ieee.org/abstract/document/10379674 [2] https://www.nature.com/articles/s41746-024-01073-0 https://www.nature.com/articles/s41746-024-01073-0 [3] https://scholar.google.com/scholar?q=digital+twin+health&hl=en&as_sdt=0,5 https://scholar.google.com/scholar?q=digital+twin+health&hl=...