3 ms·

> Taking any form of vitamin C orally still confers statistically insignificant benefits for the skin due to having to propagate and get distributed throughout

> Taking any form of vitamin C orally still confers statistically insignificant benefits for the skin due to having to propagate and get distributed throughout the entire body. Maybe not if you take it in multiple of grams, e.g. you brute force it to replace non-working GULO gene you have, that would do it in that range if not defective.

inkyoto 1y ago
Can you explain and cite a study reference? I'm not following it. Taking vitamin C by grams will give one a diarrhoea, and a pretty violent one. One of the common strategies to prolong the circulation of vitamin C is to recycle it by coupling it with, e.g. N-acetyl cysteine.
- majkinetor 1y ago
  > Taking vitamin C by grams will give one a diarrhoea, and a pretty violent one. Yes when your body gets enough of it (its called Vitamin C Flush and its not harmful), which is dynamic. I take 10+ grams and do not have diarrhoea, I might get it on 20+ IF I am healthy. I don't get it with 100g when I have influenza which is the state of the system when body requires more and SVCT pumps are active like crazy. This is trivially easy to check out yourself, you don't need a study. I have never seen a better feedback system for any drug, really. > Can you explain and cite a study reference? There are no studies about it, you need to try it yourself. Vitamin C is non-toxic and doesn't produce kidney stones, contrary to popular belief. There are medical hypothesis and Linus Pauling wrote a few books about it long time ago. https://www.sciencedirect.com/science/article/abs/pii/0306987781901262 https://www.sciencedirect.com/science/article/abs/pii/030698... Check out pharmacokinetics here: https://www.tandfonline.com/doi/abs/10.1080/13590840802305423 https://www.tandfonline.com/doi/abs/10.1080/1359084080230542... > One of the common strategies to prolong the circulation of vitamin C is to recycle it by coupling it with, e.g. N-acetyl cysteine. Yes, I take NAC too, however, the worst offender is sugar, as GLUT2 transports both C and glucose, and since its passive transporter C gets outcompeted given the levels of both. I can explain 2 decades of experience with it, if you need some info send me a note.

inkyoto 1y ago

Can you explain and cite a study reference? I'm not following it. Taking vitamin C by grams will give one a diarrhoea, and a pretty violent one. One of the common strategies to prolong the circulation of vitamin C is to recycle it by coupling it with, e.g. N-acetyl cysteine.

majkinetor 1y ago
> Taking vitamin C by grams will give one a diarrhoea, and a pretty violent one. Yes when your body gets enough of it (its called Vitamin C Flush and its not harmful), which is dynamic. I take 10+ grams and do not have diarrhoea, I might get it on 20+ IF I am healthy. I don't get it with 100g when I have influenza which is the state of the system when body requires more and SVCT pumps are active like crazy. This is trivially easy to check out yourself, you don't need a study. I have never seen a better feedback system for any drug, really. > Can you explain and cite a study reference? There are no studies about it, you need to try it yourself. Vitamin C is non-toxic and doesn't produce kidney stones, contrary to popular belief. There are medical hypothesis and Linus Pauling wrote a few books about it long time ago. https://www.sciencedirect.com/science/article/abs/pii/0306987781901262 https://www.sciencedirect.com/science/article/abs/pii/030698... Check out pharmacokinetics here: https://www.tandfonline.com/doi/abs/10.1080/13590840802305423 https://www.tandfonline.com/doi/abs/10.1080/1359084080230542... > One of the common strategies to prolong the circulation of vitamin C is to recycle it by coupling it with, e.g. N-acetyl cysteine. Yes, I take NAC too, however, the worst offender is sugar, as GLUT2 transports both C and glucose, and since its passive transporter C gets outcompeted given the levels of both. I can explain 2 decades of experience with it, if you need some info send me a note.