I think the main problem is conflation and averaging out experiences to the general population. There are distinct subsets of people who react to things very di

I think the main problem is conflation and averaging out experiences to the general population. There are distinct subsets of people who react to things very differently to the others and the focus should be on first finding out if someone is in a particular group. I do a lot of DIY psychopharmacology, mostly modafinil and amitriptyline, in a successful effort to reduce ME/CFS/hEDS related brain fog. I’ve given modafinil to normal people and they tend not to notice any effects where for me it’s a super strong drug that’ll keep me wired unless I take other drugs to calm down. I think quite a large subset of human behavior is seeking self medication for genetic anxiety disorders and I think in knowing the mechanisms people can avoid stumbling around in the dark and go directly towards things that work.