3 ms·

You don't need to take that much. LD50 is surprisingly close to the normal dose, and possible to do if you don't realise that cold remedies contain it (or that

You don't need to take that much. LD50 is surprisingly close to the normal dose, and possible to do if you don't realise that cold remedies contain it (or that aminocetophen and paracetamol are the same thing!)

hallway_monitor 1y ago
I avoid it at all costs because of the possibility of liver damage. Ibuprofen seems to have the same effect without potentially serious side effects.
- ValentinPearce 1y ago
  Ibuprofen is anti inflammatory which paracetamol isn't. IIRC this means ibuprofen can hide infections. I had a doctor friend who avoided its use as generic pain relief for that reason.
  - deleted 1y ago
    [deleted]
  - kimixa 1y ago
    But for muscular/joint pain the anti-inflammatory aspect is a feature, not a bug. And I'd guess that's what most long term user's target is?
- tecleandor 1y ago
  People will still happily use paracetamol when drinking or "for hangover" (headache and all that), hitting their liver really hard. :(
- SoftTalker 1y ago
  I take the OG: Aspirin.
- ocrow 1y ago
  The drawback of Ibuprofen is that it tends to cause damage to stomach and intestinal linings. That's why you are advised to take with food and/or lots of water. You don't want it absorbing all in one place. Long term use exacerbates the effect, making it more likely to cause ulcers and eventually internal bleeding. My partner ended up in the hospital with a serious internal bleed caused by taking Ibuprofen daily for chronic pain. I'm not saying don't use it, just be aware of the risks. https://pubmed.ncbi.nlm.nih.gov/9715832/ https://pubmed.ncbi.nlm.nih.gov/9715832/
  - colaco 1y ago
    And also kidney failure in prolonged use, usually in patients with any sort of previous kidney damage.
  - lq9AJ8yrfs 1y ago
    Ibuprofen is possibly worse than that, it seems that it may interfere with sex hormones. [1] This 2017 study I found in 30s of searching is seemingly underpowered at n=30 or so, but the (preliminary) implication is awful enough that I won't give my boys ibuprofen at all. Out of abundance of caution. They can have naproxen or acetaminophen instead -- we keep those out of reach and teach our children not to touch them without adults. Perhaps there is some more recent research? [1] https://www.pnas.org/doi/abs/10.1073/pnas.1715035115 https://www.pnas.org/doi/abs/10.1073/pnas.1715035115
- qart 1y ago
  https://x.com/theliverdr/status/1908363713771425946 https://x.com/theliverdr/status/1908363713771425946 Again and again, this hepatologist makes his message clear: "Acetaminophen (Paracetamol) is the safest anti-fever and anti-pain medicine even among patients with liver disease. It is the first choice for fever and pain management even in advanced cirrhosis." Look for some of his other posts on the topic for studies and citations.
- ChrisMarshallNY 1y ago
  I know folks that got ulcers; from both ibuprofen, and Aleve. I take acetaminophen, but only occasionally.
- refurb 1y ago
  Ibuprofen and other NSAID result in a ton of hospitalizations each year due to gastric bleeding.
refurb 1y ago
The LD50 is 10x the standard dose (5 g vs 0.5 g) And the people that have serious toxicity at 5 g are likely already sensitive due to alcohol intake, malnutrition, etc. For a healthy, well fed human who isn’t consuming alcohol the dose that causes serious issues is closer to 20x

hallway_monitor 1y ago

I avoid it at all costs because of the possibility of liver damage. Ibuprofen seems to have the same effect without potentially serious side effects.

ValentinPearce 1y ago
Ibuprofen is anti inflammatory which paracetamol isn't. IIRC this means ibuprofen can hide infections. I had a doctor friend who avoided its use as generic pain relief for that reason.
- deleted 1y ago
  [deleted]
- kimixa 1y ago
  But for muscular/joint pain the anti-inflammatory aspect is a feature, not a bug. And I'd guess that's what most long term user's target is?
tecleandor 1y ago
People will still happily use paracetamol when drinking or "for hangover" (headache and all that), hitting their liver really hard. :(
SoftTalker 1y ago
I take the OG: Aspirin.
ocrow 1y ago
The drawback of Ibuprofen is that it tends to cause damage to stomach and intestinal linings. That's why you are advised to take with food and/or lots of water. You don't want it absorbing all in one place. Long term use exacerbates the effect, making it more likely to cause ulcers and eventually internal bleeding. My partner ended up in the hospital with a serious internal bleed caused by taking Ibuprofen daily for chronic pain. I'm not saying don't use it, just be aware of the risks. https://pubmed.ncbi.nlm.nih.gov/9715832/ https://pubmed.ncbi.nlm.nih.gov/9715832/
- colaco 1y ago
  And also kidney failure in prolonged use, usually in patients with any sort of previous kidney damage.
- lq9AJ8yrfs 1y ago
  Ibuprofen is possibly worse than that, it seems that it may interfere with sex hormones. [1] This 2017 study I found in 30s of searching is seemingly underpowered at n=30 or so, but the (preliminary) implication is awful enough that I won't give my boys ibuprofen at all. Out of abundance of caution. They can have naproxen or acetaminophen instead -- we keep those out of reach and teach our children not to touch them without adults. Perhaps there is some more recent research? [1] https://www.pnas.org/doi/abs/10.1073/pnas.1715035115 https://www.pnas.org/doi/abs/10.1073/pnas.1715035115
qart 1y ago
https://x.com/theliverdr/status/1908363713771425946 https://x.com/theliverdr/status/1908363713771425946 Again and again, this hepatologist makes his message clear: "Acetaminophen (Paracetamol) is the safest anti-fever and anti-pain medicine even among patients with liver disease. It is the first choice for fever and pain management even in advanced cirrhosis." Look for some of his other posts on the topic for studies and citations.
ChrisMarshallNY 1y ago
I know folks that got ulcers; from both ibuprofen, and Aleve. I take acetaminophen, but only occasionally.
refurb 1y ago
Ibuprofen and other NSAID result in a ton of hospitalizations each year due to gastric bleeding.

refurb 1y ago

The LD50 is 10x the standard dose (5 g vs 0.5 g) And the people that have serious toxicity at 5 g are likely already sensitive due to alcohol intake, malnutrition, etc. For a healthy, well fed human who isn’t consuming alcohol the dose that causes serious issues is closer to 20x