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I think a better title here than: > The first non-opoid [sic] painkiller might be: > The first non-opioid nociceptive pain-killer Nociceptive pain being tha

by OJFord 1y ago

I think a better title here than: > The first non-opoid [sic] painkiller might be: > The first non-opioid nociceptive pain-killer Nociceptive pain being that by actual damage to tissue, as opposed to neuropathic pain like a headache or inflammation that you might take a (non-opioid!) NSAID for. https://www.iasp-pain.org/resources/terminology/ https://www.iasp-pain.org/resources/terminology/

deleted 1y ago
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szszrk 1y ago
Will that terminology explanation be a subtitle? :)
- OJFord 1y ago
  Well my comment will still be here, and at least having the qualifier in the title is a pointer to look it up if needed, or to hint 'oh right ok it doesn't mean of all things, I guess paracetamol does not kill nociceptive pain, whatever that is'.
biofox 1y ago
I'm a neuroscientist by training, and that doesn't match my understanding (although the definitions might have changed). Inflammation would be an instance of nociceptive pain, and an NSAID would alleviate it by reducing the inflammation; and most tissue damage will result in inflammation. Neuropathic pain, on the other hand, would be due to damage of the nerves themselves, and NSAIDs are completely useless here (ask anyone with sciatica or other nerve entrapment)
- OJFord 1y ago
  I'm happy to take that correction - I have no training in any relevant field - I was just trying to follow the description in TFA, which links indirectly to my link above in the second paragraph or so as 'nociceptive pain'; from which I inferred that's all it's talking about and existing non-opioids must therefore not target that. Perhaps non-inflammatory (or generically) nociceptive pain killing is the point. (Which is getting a bit specific for such a broad title isn't it. Does 'painkiller' ordinarily have such a narrow meaning in your experience?)
EasyMark 1y ago
I guess that would make sense in a scientific paper or journal, but most people would have no idea what that means and just make for a confusing title that would turn people off from reading it. Almost everyone has heard of opiates in the evening news or social media.
- badmintonbaseba 1y ago
  Also everyone heard of pain killers that are non-opioid, so you can't really get around explaining why this one is novel.
- OJFord 1y ago
  And almost all those people have 'painkillers' such as paracetamol and ibuprofen in their cupboard, which they know not to be opiates. The point isn't to accurately describe it as 'nociceptive' (which I've never heard of before either) and have that be understood, it's to qualify it such that it isn't confusing or sounding like an historical tale of how whatever the first NSAID/analgesic was came to be.

by OJFord 1y ago

deleted 1y ago

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szszrk 1y ago

Will that terminology explanation be a subtitle? :)

OJFord 1y ago
Well my comment will still be here, and at least having the qualifier in the title is a pointer to look it up if needed, or to hint 'oh right ok it doesn't mean of all things, I guess paracetamol does not kill nociceptive pain, whatever that is'.

biofox 1y ago

I'm a neuroscientist by training, and that doesn't match my understanding (although the definitions might have changed). Inflammation would be an instance of nociceptive pain, and an NSAID would alleviate it by reducing the inflammation; and most tissue damage will result in inflammation. Neuropathic pain, on the other hand, would be due to damage of the nerves themselves, and NSAIDs are completely useless here (ask anyone with sciatica or other nerve entrapment)

OJFord 1y ago
I'm happy to take that correction - I have no training in any relevant field - I was just trying to follow the description in TFA, which links indirectly to my link above in the second paragraph or so as 'nociceptive pain'; from which I inferred that's all it's talking about and existing non-opioids must therefore not target that. Perhaps non-inflammatory (or generically) nociceptive pain killing is the point. (Which is getting a bit specific for such a broad title isn't it. Does 'painkiller' ordinarily have such a narrow meaning in your experience?)

EasyMark 1y ago

I guess that would make sense in a scientific paper or journal, but most people would have no idea what that means and just make for a confusing title that would turn people off from reading it. Almost everyone has heard of opiates in the evening news or social media.

badmintonbaseba 1y ago
Also everyone heard of pain killers that are non-opioid, so you can't really get around explaining why this one is novel.
OJFord 1y ago
And almost all those people have 'painkillers' such as paracetamol and ibuprofen in their cupboard, which they know not to be opiates. The point isn't to accurately describe it as 'nociceptive' (which I've never heard of before either) and have that be understood, it's to qualify it such that it isn't confusing or sounding like an historical tale of how whatever the first NSAID/analgesic was came to be.