4 ms·

Anyone better than me in pharmacology able to explain how suzetrigine compares to (high dosage?) ambroxol? They are both Nav1.8 blockers, but in Germany you ca

Anyone better than me in pharmacology able to explain how suzetrigine compares to (high dosage?) ambroxol? They are both Nav1.8 blockers, but in Germany you can get lots of ambroxol for cheap and OTC.

ck2 1y ago
Oh ambroxol is very interesting! And a cheap generic Really appreciate you mentioning it https://pmc.ncbi.nlm.nih.gov/articles/PMC6494067/ https://pmc.ncbi.nlm.nih.gov/articles/PMC6494067/
- Traubenfuchs 1y ago
  Ambroxol has many interesting fringe applications. It potentiates antibiotic effect in lung infections, including tuberculosis, treats painful hyperacusis, trigeminal neuralgia, neuropathic pain, parkinson, gaucher disease... ...and what's this? We have a surprise guest! Ambroxol significantly reduces snoring and thus suddenly becomes a candidate for a medication half the population should take! https://www.researchgate.net/publication/314424871_Evaluation_of_a_biochemical_process_to_minimize_snoring_with_ambroxol_bromhexine_in_comparison_with_their_performance_in_non_OSA_Bangladeshi_patients https://www.researchgate.net/publication/314424871_Evaluatio... It's one of those drugs that deserves way bigger interest than it gets.
  - blangk 1y ago
    Too bad its generic I guess. The cynic in me says that's why it doesn't get the interest it deserves
  - ck2 1y ago
    grain of salt with this because it's LLM and needs verification https://images2.imgbox.com/e1/b7/YaB8gjLI_o.png https://images2.imgbox.com/e1/b7/YaB8gjLI_o.png but apparently the problem with ambroxol vs suzetrigine is it is not as selective on the ion channel and not as strong (needs megadose to do similar) I cannot remember the drugs offhand but this is the same problem with other old generics for other kinds of targets suzetrigine won't be generic for years which is a shame

4 ms·

Anyone better than me in pharmacology able to explain how suzetrigine compares to (high dosage?) ambroxol? They are both Nav1.8 blockers, but in Germany you ca

by Traubenfuchs 1y ago

ck2 1y ago
Oh ambroxol is very interesting! And a cheap generic Really appreciate you mentioning it https://pmc.ncbi.nlm.nih.gov/articles/PMC6494067/ https://pmc.ncbi.nlm.nih.gov/articles/PMC6494067/
- Traubenfuchs 1y ago
  Ambroxol has many interesting fringe applications. It potentiates antibiotic effect in lung infections, including tuberculosis, treats painful hyperacusis, trigeminal neuralgia, neuropathic pain, parkinson, gaucher disease... ...and what's this? We have a surprise guest! Ambroxol significantly reduces snoring and thus suddenly becomes a candidate for a medication half the population should take! https://www.researchgate.net/publication/314424871_Evaluation_of_a_biochemical_process_to_minimize_snoring_with_ambroxol_bromhexine_in_comparison_with_their_performance_in_non_OSA_Bangladeshi_patients https://www.researchgate.net/publication/314424871_Evaluatio... It's one of those drugs that deserves way bigger interest than it gets.
  - blangk 1y ago
    Too bad its generic I guess. The cynic in me says that's why it doesn't get the interest it deserves
  - ck2 1y ago
    grain of salt with this because it's LLM and needs verification https://images2.imgbox.com/e1/b7/YaB8gjLI_o.png https://images2.imgbox.com/e1/b7/YaB8gjLI_o.png but apparently the problem with ambroxol vs suzetrigine is it is not as selective on the ion channel and not as strong (needs megadose to do similar) I cannot remember the drugs offhand but this is the same problem with other old generics for other kinds of targets suzetrigine won't be generic for years which is a shame