If you want to manually manage envs and you're using conda, you can activate the env in a shell wrapper for your python script, like so (this is with conda)

If you want to manually manage envs and you're using conda, you can activate the env in a shell wrapper for your python script, like so (this is with conda) #!/usr/bin/env bash eval "$(conda shell.bash hook)" conda activate myenv python myscript Admittedly this isn't self contained like the PEP 723 solution.