This is correct (if cells higher than 2048 are allowed, which varies by implementation.) But the game can still be represented in fewer than 16×18 bits, becaus

This is correct (if cells higher than 2048 are allowed, which varies by implementation.) But the game can still be represented in fewer than 16×18 bits, because not every board state is reachable. There can't be more than one cell with the maximum value. And if that is present, then there can't be more than one cell with the next-highest value, and so on. So you could devise some scheme to enumerate all reachable states and skip unreachable ones, and it would take fewer than 16×18 bits to indicate which one. The upper bound is at least bounded by ignoring representing the maximum value and then using 4 bits to indicate its necessarily singular position. There are also some other unreachable configurations, like if many copies of the same value are touching each other, since at least one pair of them would have been combined on the previous move.