There are plausible scenarios where a region can go down for days or more at a time, like natural disasters. I'm not terribly worried about a region going away

There are plausible scenarios where a region can go down for days or more at a time, like natural disasters. I'm not terribly worried about a region going away _forever_, but during a regional outage long enough to start losing business, having data in multiple regions is important so you can restore in another region (if you aren't able to fail over quickly).