3 ms·
Why are A and B considered to belong to the same "system"? They combine with each other combinatorially in exactly the same way that rhesus factor combines with
by thaumasiotes 1y ago
Why are A and B considered to belong to the same "system"? They combine with each other combinatorially in exactly the same way that rhesus factor combines with them, and presumably the same way that all other systems combine with all other systems.
- thechao 1y agoHold my beer; I'm gonna middlebrow this! My best guess (dimly remembered from drawing blood for testing in my lab) is that these "groups" (systems?) all live at the same place on the chromosomes that do/n't express them — they're alleles.
- hn_throwaway_99 1y agoBlood type systems are defined by the single allele that encodes the antigens (as you point out, sometimes multiple antigens per allele). This table shows all of the different blood type systems, https://www.isbtweb.org/resource/tableofbloodgroupsystems.html https://www.isbtweb.org/resource/tableofbloodgroupsystems.ht..., and the chromosomal location of the respective allele.
- wbl 1y agoABO all involve the same gene locus and the same protein just different glycans that get added. https://en.m.wikipedia.org/wiki/ABO_(gene) https://en.m.wikipedia.org/wiki/ABO_(gene)