6 ms·

Cannabis scientists are trying to find a predictable, reliable product (2020)

34 points by dr_dshiv 1y ago

DrillShopper 1y ago
Hey, let me know if you need anyone to help with that research.
javaunsafe2019 1y ago
[flagged]
Traubenfuchs 1y ago
https://archive.ph/6dyjb https://archive.ph/6dyjb
- deleted 1y ago
  [deleted]
- Michiolet 1y ago
  I want hacker apps please
readthenotes1 1y ago
Cemetery plots or stents, if you can trust the Science E. g., https://www.acc.org/Latest-in-Cardiology/Journal-Scans/2025/03/24/13/52/Cannabis-Use-Substantially-Increases-Risk-of-Heart-Attack-acc-2025 https://www.acc.org/Latest-in-Cardiology/Journal-Scans/2025/... https://www.healthline.com/health-news/cannabis-use-cardiovascular-disease-death-risk#Cannabis-and-heart-health https://www.healthline.com/health-news/cannabis-use-cardiova...
- naruhodo 1y ago
  I've seen the same study reported in non-science media today as well. As is established tradition, the scientists did a meta-analysis of studies that did not control for method of administration. (Your second link - healthline - notes that: "There was no delineation in the analysis, however, on the risks of smoking cannabis compared to ingesting it."). I have yet to see any evidence that edibles or dry-herb vaporisers have the same harms as smoking. I have absolutely no problem with believing that smoking cannabis is harmful. There is clearly value in warning people about smoking cannabis. However, I would like to see some nuance around method of administration. I will continue to treat my health issues with oil-based tinctures and the occasional bit of dry-herb vaped flower.
  - pinoy420 1y ago
    [dead]
  - danielbln 1y ago
    THC increases heartrate, so it's not entirely implausible that there is a knock-on effect on cardiovascular health, even when ingested. More research needed, however, and yes, smoking is always bad.
- rusk 1y ago
  Surprised that after all these years we still have to point out “correlation is not causation”
pipeline_peak 1y ago
This article reads like something Vice published in 2012. Quite honestly, I only made it 1/3 through. We’ve all been to those glass case dispensaries by now. The world of weed isn’t that new and exciting anymore, c’mon guys… They seemed to discuss reducing as much of the plant as possible to make something less variable, but smoking has gotten so many improvements what about edibles? Just make a THC capsule that works whenever I take it, cumulatively if possible. Not lousy gummies that I can only take once in a 24 hour cycle as my tolerance skyrockets. Followed by a hangover effect caused by as little as 10 mg. Those current gummies, if my dosage isn’t enough and I take more later (low and slow), the second dose never quite catches up to the first one. It’s just one big non euphoric haze. I’ve tried sublingual RSO, tinctures, and edibles. The current world of non smokable weed needs a lot of fundamental changes. It’s almost like edibles are stuck in the 70’s era of pot brownies but they reduced it down to a gummy.
- rusk 1y ago
  You could try decarbed weed in gel caps. It’s just the first stage of edibles without all the extra food gunk.
  - pipeline_peak 1y ago
    Unless I’ve mistaken what you suggested, It needs either a carrier oil or ethanol to be psychoactive, at least how things stand now. And if what you suggested is like anything that I’ve tried, it’s the same problem. They just aren’t as reliable or consistent as other oral drugs. There needs to be research done so we can do away with smoking. People who take opioids don’t need a pipe, why do we?
    - rusk 1y ago
      Yes you need to take it with something. But you don’t have to be messing about with somebody else’s idea of what a nice treat is. We have vaporisers, if you want a safe reliable non-pipe solution for self administration.
      - 1y ago
rurban 1y ago
> weather or insects Growers aren't really worried about them. They worried about the deadly HLVd virus. https://ceainsight.com/research-hop-latent-viroid-cannabis/ https://ceainsight.com/research-hop-latent-viroid-cannabis/ Weather is irrelevant, it's all in hightech greenhouses, with strong LED lighting, automatic watering, climate control, no insects.
- CjHuber 1y ago
  Oh there will definitely be insects indoors if you are not careful to no bring them in. But yeah HLVd is currently a real plant pandemic
- ulf-77723 1y ago
  Insects and Microorganisms are indeed wanted from my perspective - I grow in living soil and cherish any form of live. There are studies about certain fungi in the soil which lead to peach aroma and flowery terpenes. This plant is plenty of tastes: gasy and fruity, herbful. When you get a Banana Punch it feels like a fruit ensemble and the sweetest fruits just like grapes do need terroir
achenet 1y ago
https://archive.ph/6dyjb https://archive.ph/6dyjb
echelon_musk 1y ago
> to make cannabis as popular as booze requires solving that original problem: It’s hard to imagine millions of people becoming new recreational users without being able to promise them that the product they’re spending money on ... will give them the effect they want. > it remains to be seen whether that’s even possible with a plant as complex as cannabis Cannabis doesn't work like this. It has been tried and the end result was Sativex. It doesn't work as well as actual cannabis. It's like trying to replace coffee with caffeine. There's something like ~1000 compounds in coffee. The effects are not the same. There's an entourage effect going on in cannabis that's extremely hard to replicate. Even buds on different parts of the same plant will have different profiles. Also the sativa vs indica classification is almost completely meaningless nonsense these days. Does it have high THCV? Then maybe it's what was once called sativa. Was it an indica harvested before there were any amber trichomes? Maybe it has 'sativa' effects etc.
- Cthulhu_ 1y ago
  Isn't it also the same with alcohol, at least the beverage that people drink? Wine especially is very susceptible to conditions; soil, weather, strain, location, barrels, harvest time, aging conditions/temperature, etc. Sure, the alcohol chemical is the same everywhere, but so is THC/CBD when you want to reduce it like that. Watered down ethanol is probably a thing but few people drink it like that.
  - wizzwizz4 1y ago
    That affects the taste of the alcohol, but not really the psychoactive effects. Booze is booze is booze.
    - portaouflop 1y ago
      I disagree - personally I have vastly different effects wether I drink beer, whiskey, wine or jägermeister and I’m sure most people feel the same.
      - 1y ago
walthamstow 1y ago
The bit about pure THC rings true. My guy here in Britain sells live resin but occasionally when he's out of that, I'll buy one of his homebrew dab carts. He says they are 0.4ml live resin, 0.5ml THC distillate and 0.1ml terpenes. They weigh so much heavier on my brain, and have little euphoria, compared to live resin or regular old nugs.
- infintropy 1y ago
  Are you controlling for cannabinoid tolerance? I have a hard time evaluating products as I never control for this when switching.
TimByte 1y ago
The comparison to tuning a symphony vs isolating a single instrument really stuck with me. Trying to turn such a complex, variable plant into a mass-market, repeatable product seems like an uphill battle
kbrkbr 1y ago
Maybe it's only me, but "cannabis scientists" seems another one of these nonsense words that content creators make up to make their product sound smart. It slowly diffuses into mainstream journalism, and I'm really sorry for the NYTimes if their readers don't know what a chemist or biologist is. Call me Don Quixote, but I think it's a slippery slope.
- echelon_musk 1y ago
  At my office there was an out of order sign on a toilet door saying an engineer would fix the stall soon. I remember when toilet engineers were called plumbers!
- johnea 1y ago
  Do you recall when Colorado first legalized? NYTimes sent a journalist to Denver, who bought a chocolate bar at a dispensary, went back to their hotel room and ate it. Then, started seeing kaleidoscopes and curled up into the fetal position until it all wore off. No long term harm of course, but one freaked out New Yorker. Turned out, the chocolate bar was 8 doses! and the journalist had NEVER used any cannabis in their life prior to ingesting. This is one reason I'm not an advocate of edibles, or extracted products in general. So, that's the context of this article. NYT and NY in general are fighting cannabis all the way. The east coast of the US really is 50 years behind, and not just regarding cannabis. I also agree with your criticism of the news hype of "cannabis scientists". As I say in my article comment, just smoke the plant, stop trying to turn it into jet fuel...
  - DrillShopper 1y ago
    > NYTimes sent a journalist to Denver That was none other than Maureen Dowd, famous as a warmonger and booster of Trump's foreign policy in his first term: https://www.nytimes.com/2014/06/04/opinion/dowd-dont-harsh-our-mellow-dude.html https://www.nytimes.com/2014/06/04/opinion/dowd-dont-harsh-o... Not surprised that reading and decision making aren't her strong skills.
johnea 1y ago
"Cannabis scientists"? Who needs 'em... Grow a plant, Smoke it, Enjoy... All of the extracts, derivatives, and edibles ARE the problem. Stop concentrating the "active ingredients", and use a minimally selected variety of the plant. As usual, all the effort going into making a shit ton of money for some rich asshole are f_cking up the original item for everyone else. NOTE: maybe you're also familiar with a similar course of events on this thing called "the internet"?
deleted 1y ago
[deleted]
deleted 1y ago
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deleted 1y ago
[deleted]

34 points by dr_dshiv 1y ago

DrillShopper 1y ago

Hey, let me know if you need anyone to help with that research.

javaunsafe2019 1y ago

[flagged]

Traubenfuchs 1y ago

https://archive.ph/6dyjb https://archive.ph/6dyjb

deleted 1y ago
[deleted]
Michiolet 1y ago
I want hacker apps please

readthenotes1 1y ago

Cemetery plots or stents, if you can trust the Science E. g., https://www.acc.org/Latest-in-Cardiology/Journal-Scans/2025/03/24/13/52/Cannabis-Use-Substantially-Increases-Risk-of-Heart-Attack-acc-2025 https://www.acc.org/Latest-in-Cardiology/Journal-Scans/2025/... https://www.healthline.com/health-news/cannabis-use-cardiovascular-disease-death-risk#Cannabis-and-heart-health https://www.healthline.com/health-news/cannabis-use-cardiova...

naruhodo 1y ago
I've seen the same study reported in non-science media today as well. As is established tradition, the scientists did a meta-analysis of studies that did not control for method of administration. (Your second link - healthline - notes that: "There was no delineation in the analysis, however, on the risks of smoking cannabis compared to ingesting it."). I have yet to see any evidence that edibles or dry-herb vaporisers have the same harms as smoking. I have absolutely no problem with believing that smoking cannabis is harmful. There is clearly value in warning people about smoking cannabis. However, I would like to see some nuance around method of administration. I will continue to treat my health issues with oil-based tinctures and the occasional bit of dry-herb vaped flower.
- pinoy420 1y ago
  [dead]
- danielbln 1y ago
  THC increases heartrate, so it's not entirely implausible that there is a knock-on effect on cardiovascular health, even when ingested. More research needed, however, and yes, smoking is always bad.
rusk 1y ago
Surprised that after all these years we still have to point out “correlation is not causation”

pipeline_peak 1y ago

This article reads like something Vice published in 2012. Quite honestly, I only made it 1/3 through. We’ve all been to those glass case dispensaries by now. The world of weed isn’t that new and exciting anymore, c’mon guys… They seemed to discuss reducing as much of the plant as possible to make something less variable, but smoking has gotten so many improvements what about edibles? Just make a THC capsule that works whenever I take it, cumulatively if possible. Not lousy gummies that I can only take once in a 24 hour cycle as my tolerance skyrockets. Followed by a hangover effect caused by as little as 10 mg. Those current gummies, if my dosage isn’t enough and I take more later (low and slow), the second dose never quite catches up to the first one. It’s just one big non euphoric haze. I’ve tried sublingual RSO, tinctures, and edibles. The current world of non smokable weed needs a lot of fundamental changes. It’s almost like edibles are stuck in the 70’s era of pot brownies but they reduced it down to a gummy.

rusk 1y ago
You could try decarbed weed in gel caps. It’s just the first stage of edibles without all the extra food gunk.
- pipeline_peak 1y ago
  Unless I’ve mistaken what you suggested, It needs either a carrier oil or ethanol to be psychoactive, at least how things stand now. And if what you suggested is like anything that I’ve tried, it’s the same problem. They just aren’t as reliable or consistent as other oral drugs. There needs to be research done so we can do away with smoking. People who take opioids don’t need a pipe, why do we?
  - rusk 1y ago
    Yes you need to take it with something. But you don’t have to be messing about with somebody else’s idea of what a nice treat is. We have vaporisers, if you want a safe reliable non-pipe solution for self administration.
    - 1y ago

rurban 1y ago

> weather or insects Growers aren't really worried about them. They worried about the deadly HLVd virus. https://ceainsight.com/research-hop-latent-viroid-cannabis/ https://ceainsight.com/research-hop-latent-viroid-cannabis/ Weather is irrelevant, it's all in hightech greenhouses, with strong LED lighting, automatic watering, climate control, no insects.

CjHuber 1y ago
Oh there will definitely be insects indoors if you are not careful to no bring them in. But yeah HLVd is currently a real plant pandemic
ulf-77723 1y ago
Insects and Microorganisms are indeed wanted from my perspective - I grow in living soil and cherish any form of live. There are studies about certain fungi in the soil which lead to peach aroma and flowery terpenes. This plant is plenty of tastes: gasy and fruity, herbful. When you get a Banana Punch it feels like a fruit ensemble and the sweetest fruits just like grapes do need terroir

achenet 1y ago

https://archive.ph/6dyjb https://archive.ph/6dyjb

echelon_musk 1y ago

> to make cannabis as popular as booze requires solving that original problem: It’s hard to imagine millions of people becoming new recreational users without being able to promise them that the product they’re spending money on ... will give them the effect they want. > it remains to be seen whether that’s even possible with a plant as complex as cannabis Cannabis doesn't work like this. It has been tried and the end result was Sativex. It doesn't work as well as actual cannabis. It's like trying to replace coffee with caffeine. There's something like ~1000 compounds in coffee. The effects are not the same. There's an entourage effect going on in cannabis that's extremely hard to replicate. Even buds on different parts of the same plant will have different profiles. Also the sativa vs indica classification is almost completely meaningless nonsense these days. Does it have high THCV? Then maybe it's what was once called sativa. Was it an indica harvested before there were any amber trichomes? Maybe it has 'sativa' effects etc.

Cthulhu_ 1y ago
Isn't it also the same with alcohol, at least the beverage that people drink? Wine especially is very susceptible to conditions; soil, weather, strain, location, barrels, harvest time, aging conditions/temperature, etc. Sure, the alcohol chemical is the same everywhere, but so is THC/CBD when you want to reduce it like that. Watered down ethanol is probably a thing but few people drink it like that.
- wizzwizz4 1y ago
  That affects the taste of the alcohol, but not really the psychoactive effects. Booze is booze is booze.
  - portaouflop 1y ago
    I disagree - personally I have vastly different effects wether I drink beer, whiskey, wine or jägermeister and I’m sure most people feel the same.
    - 1y ago

walthamstow 1y ago

The bit about pure THC rings true. My guy here in Britain sells live resin but occasionally when he's out of that, I'll buy one of his homebrew dab carts. He says they are 0.4ml live resin, 0.5ml THC distillate and 0.1ml terpenes. They weigh so much heavier on my brain, and have little euphoria, compared to live resin or regular old nugs.

infintropy 1y ago
Are you controlling for cannabinoid tolerance? I have a hard time evaluating products as I never control for this when switching.

TimByte 1y ago

The comparison to tuning a symphony vs isolating a single instrument really stuck with me. Trying to turn such a complex, variable plant into a mass-market, repeatable product seems like an uphill battle

kbrkbr 1y ago

Maybe it's only me, but "cannabis scientists" seems another one of these nonsense words that content creators make up to make their product sound smart. It slowly diffuses into mainstream journalism, and I'm really sorry for the NYTimes if their readers don't know what a chemist or biologist is. Call me Don Quixote, but I think it's a slippery slope.

echelon_musk 1y ago
At my office there was an out of order sign on a toilet door saying an engineer would fix the stall soon. I remember when toilet engineers were called plumbers!
johnea 1y ago
Do you recall when Colorado first legalized? NYTimes sent a journalist to Denver, who bought a chocolate bar at a dispensary, went back to their hotel room and ate it. Then, started seeing kaleidoscopes and curled up into the fetal position until it all wore off. No long term harm of course, but one freaked out New Yorker. Turned out, the chocolate bar was 8 doses! and the journalist had NEVER used any cannabis in their life prior to ingesting. This is one reason I'm not an advocate of edibles, or extracted products in general. So, that's the context of this article. NYT and NY in general are fighting cannabis all the way. The east coast of the US really is 50 years behind, and not just regarding cannabis. I also agree with your criticism of the news hype of "cannabis scientists". As I say in my article comment, just smoke the plant, stop trying to turn it into jet fuel...
- DrillShopper 1y ago
  > NYTimes sent a journalist to Denver That was none other than Maureen Dowd, famous as a warmonger and booster of Trump's foreign policy in his first term: https://www.nytimes.com/2014/06/04/opinion/dowd-dont-harsh-our-mellow-dude.html https://www.nytimes.com/2014/06/04/opinion/dowd-dont-harsh-o... Not surprised that reading and decision making aren't her strong skills.

johnea 1y ago

"Cannabis scientists"? Who needs 'em... Grow a plant, Smoke it, Enjoy... All of the extracts, derivatives, and edibles ARE the problem. Stop concentrating the "active ingredients", and use a minimally selected variety of the plant. As usual, all the effort going into making a shit ton of money for some rich asshole are f_cking up the original item for everyone else. NOTE: maybe you're also familiar with a similar course of events on this thing called "the internet"?

deleted 1y ago

[deleted]

deleted 1y ago

[deleted]

deleted 1y ago

[deleted]