4 ms·

I know people personally that psilocybin, LSD, and other substances do nothing for. All of them also have existing mental health disorders (extreme generalized

by esseph 1y ago

I know people personally that psilocybin, LSD, and other substances do nothing for. All of them also have existing mental health disorders (extreme generalized anxiety, depression, bipolar, etc.).

kbenson 1y ago
Nothing as in there is no outside noticeable change in behavior and they report no change in speaking, or nothing as it relates to the topic of this thread, in that they have no profound or spiritual experiences?
- esseph 1y ago
  They might get a slight body high even on what would otherwise be considered heroic doses for their weight. Things like lemon-tek to make the psilocybin more bioavailable were also not impactful to them, while being apparently extremely impactful for others.
  - vermilingua 1y ago
    It may be worth noting that antidepressant medication has a strong suppressing effect on psychedelics.
    - ghxst 1y ago
      Depends on the type! Generally might be true for SSRIs but not always for TCAs or lithium which can have the opposite effect. https://pubmed.ncbi.nlm.nih.gov/8788508/ https://pubmed.ncbi.nlm.nih.gov/8788508/ (just one example)
    - esseph 1y ago
      Well aware and accounted for.
      - dymk 1y ago
        If they’re doing high doses of psychedelics and only experiencing a body high, then they’re either on a drug blocking its effects, or they’re not taking a 5HT2-A agonist. They simply do not just produce a body high at high doses, you will know when you’re tripping.
        mtlmtlmtlmtl 1y ago
        This isn't completely true. Tolerance to psychedelics is a thing, and can often ve extremely long lasting. I have a friend that when given heroic doses of 2C-B(50mg or more, orally), hardly experienced more than threshold level effects. This was 2C-B tested and confirmed to have 95% purity, and it affected me exactly as expected. He was not on any drugs except hash, which is typically synergistic. In his case, according to him he yad used 2C-B very heavily many years previously, and it seems he developed an extremely high level of tolerance which remained unchanged for many years of non-use. In the cases discussed in the thread, it's possible that something similar was happening. Indeed, many antidepressants also alter serotonin receptor expression over time, and it's plausible that in some people, these effects could linger for a long time.
        dymk 1y ago
        I agree in that case, long-term SSRI and psychedelic use complicates things. But in general, I would not say the literature points to tolerance being long lasting. Tolerance is built up quickly, and then quickly lost. There have been many (reproduced) studies on the effects of psychedelics and tolerance build up, and they show it doesn't last for more than a few weeks (psilocybin / LSD).
        mtlmtlmtlmtl 1y ago
        I'd be interested to see those studies. I think there could be a couple different types of tolerance, one of which only occurs with rather heavy use. It's something I've seen reported anecdotally from a number of people who've used psychedelics very heavily. It might not show up in human studies because of ethical concerns. There could be some interesting pharmacological differences too, where this only occurs with specific drugs. The psychedelics are quite varied in terms of pharmacodynamics beyond just the 5-HT-2 receptor subfamily.
jdenning 1y ago
Many psych meds diminish/block psychedelic effects.
tlavoie 1y ago
That could be an interaction with the meds they take for those conditions, couldn't it? I seem to recall that SSRIs in particular could mitigate the effects of the hallucinogen.
- esseph 1y ago
  Yes, also that was accounted for with doctors notice and slow tapers off medications over months.
- deleted 1y ago
  [deleted]
grigri907 1y ago
Fwiw I find that, due to my antidepressants, i need 3x the dose to have the equivalent experience as my friends.
nathan_compton 1y ago
I find mushrooms in particular delightful, just not deep.
- esseph 1y ago
  Higher dose.
  - throw-qqqqq 1y ago
    EXACTLY! The same to most of the posters with “meh-effects”: up the dose! LSD and psilocybin can be very psychedelic and hallucinogenic

by esseph 1y ago

I know people personally that psilocybin, LSD, and other substances do nothing for. All of them also have existing mental health disorders (extreme generalized anxiety, depression, bipolar, etc.).

kbenson 1y ago

Nothing as in there is no outside noticeable change in behavior and they report no change in speaking, or nothing as it relates to the topic of this thread, in that they have no profound or spiritual experiences?

esseph 1y ago
They might get a slight body high even on what would otherwise be considered heroic doses for their weight. Things like lemon-tek to make the psilocybin more bioavailable were also not impactful to them, while being apparently extremely impactful for others.
- vermilingua 1y ago
  It may be worth noting that antidepressant medication has a strong suppressing effect on psychedelics.
  - ghxst 1y ago
    Depends on the type! Generally might be true for SSRIs but not always for TCAs or lithium which can have the opposite effect. https://pubmed.ncbi.nlm.nih.gov/8788508/ https://pubmed.ncbi.nlm.nih.gov/8788508/ (just one example)
  - esseph 1y ago
    Well aware and accounted for.
    - dymk 1y ago
      If they’re doing high doses of psychedelics and only experiencing a body high, then they’re either on a drug blocking its effects, or they’re not taking a 5HT2-A agonist. They simply do not just produce a body high at high doses, you will know when you’re tripping.
      - mtlmtlmtlmtl 1y ago
        This isn't completely true. Tolerance to psychedelics is a thing, and can often ve extremely long lasting. I have a friend that when given heroic doses of 2C-B(50mg or more, orally), hardly experienced more than threshold level effects. This was 2C-B tested and confirmed to have 95% purity, and it affected me exactly as expected. He was not on any drugs except hash, which is typically synergistic. In his case, according to him he yad used 2C-B very heavily many years previously, and it seems he developed an extremely high level of tolerance which remained unchanged for many years of non-use. In the cases discussed in the thread, it's possible that something similar was happening. Indeed, many antidepressants also alter serotonin receptor expression over time, and it's plausible that in some people, these effects could linger for a long time.
        dymk 1y ago
        I agree in that case, long-term SSRI and psychedelic use complicates things. But in general, I would not say the literature points to tolerance being long lasting. Tolerance is built up quickly, and then quickly lost. There have been many (reproduced) studies on the effects of psychedelics and tolerance build up, and they show it doesn't last for more than a few weeks (psilocybin / LSD).
        mtlmtlmtlmtl 1y ago
        I'd be interested to see those studies. I think there could be a couple different types of tolerance, one of which only occurs with rather heavy use. It's something I've seen reported anecdotally from a number of people who've used psychedelics very heavily. It might not show up in human studies because of ethical concerns. There could be some interesting pharmacological differences too, where this only occurs with specific drugs. The psychedelics are quite varied in terms of pharmacodynamics beyond just the 5-HT-2 receptor subfamily.

jdenning 1y ago

Many psych meds diminish/block psychedelic effects.

tlavoie 1y ago

That could be an interaction with the meds they take for those conditions, couldn't it? I seem to recall that SSRIs in particular could mitigate the effects of the hallucinogen.

esseph 1y ago
Yes, also that was accounted for with doctors notice and slow tapers off medications over months.
deleted 1y ago
[deleted]

grigri907 1y ago

Fwiw I find that, due to my antidepressants, i need 3x the dose to have the equivalent experience as my friends.

nathan_compton 1y ago

I find mushrooms in particular delightful, just not deep.

esseph 1y ago
Higher dose.
- throw-qqqqq 1y ago
  EXACTLY! The same to most of the posters with “meh-effects”: up the dose! LSD and psilocybin can be very psychedelic and hallucinogenic