2 ms·

I've flagged this submission. The title is editorialized and indicates an event occurred which didn't (or at least is not supported by this paper). The South Ko

I've flagged this submission. The title is editorialized and indicates an event occurred which didn't (or at least is not supported by this paper). The South Korean lab did not make bird flu 100% lethal, they studied an in-the-wild bird flu and ran experiments on mice.

greenavocado 1y ago
[flagged]
- Jtsummers 1y ago
  It's not BS. You did editorialize the title, that's obvious to everyone. And your title also suggests that the researchers modified the virus, they did not. They used an existing mutation in their experiments.
  - greenavocado 1y ago
    I changed the title. Please unflag.
    - Jtsummers 1y ago
      > Please unflag. No. Your title is still editorialized. EDIT: And to add, from how you've edited your original reply to me I'm disinclined to ever do anything for you, no matter how politely you phrase it.
      - greenavocado 1y ago
        Fine, I changed it to the utterly useless original title to satisfy the HN rule of "no editorialization."
  - noworriesnate 1y ago
    Existing as in another lab created that mutation or existing as in that mutation evolved naturally in the wild?
    - Jtsummers 1y ago
      Per the paper, found in the wild. > We isolated an HPAI H5N1 clade 2.3.4.4b virus from wild birds in Korea with 96% E and 4% K at amino acid position 627 of PB2. To investigate the genomic characteristics of this clade regarding mammalian adaptation, we studied the replication and transmission of the H5N1 virus in mice.
dogma1138 1y ago
The event as in the research has occurred, and it was 100% lethal to all mammalian subjects and also the conclusion of the research is that the pathway would be applicable to all mammals. So a lab in fact has created a highly contagious flu virus (far higher than regular flu) through gain of function research which has indeed killed 100% of the subjects which contracted it even if they were only mice.
- Jtsummers 1y ago
  > So a lab in fact has created a highly contagious flu virus This paper does not appear to support that. They indicate the source was an existing, in the wild virus. >> We isolated an HPAI H5N1 clade 2.3.4.4b virus from wild birds in Korea with 96% E and 4% K at amino acid position 627 of PB2. To investigate the genomic characteristics of this clade regarding mammalian adaptation, we studied the replication and transmission of the H5N1 virus in mice.
  - dogma1138 1y ago
    That was the gain of function research. They infected mice with a wild strain that already was pre-positioned to better infect mammals used super high viral loads for that then watched as the mutations which promote mammalian infection evolved and exposed challenge mice to the newly developed strain.

greenavocado 1y ago

[flagged]

Jtsummers 1y ago
It's not BS. You did editorialize the title, that's obvious to everyone. And your title also suggests that the researchers modified the virus, they did not. They used an existing mutation in their experiments.
- greenavocado 1y ago
  I changed the title. Please unflag.
  - Jtsummers 1y ago
    > Please unflag. No. Your title is still editorialized. EDIT: And to add, from how you've edited your original reply to me I'm disinclined to ever do anything for you, no matter how politely you phrase it.
    - greenavocado 1y ago
      Fine, I changed it to the utterly useless original title to satisfy the HN rule of "no editorialization."
- noworriesnate 1y ago
  Existing as in another lab created that mutation or existing as in that mutation evolved naturally in the wild?
  - Jtsummers 1y ago
    Per the paper, found in the wild. > We isolated an HPAI H5N1 clade 2.3.4.4b virus from wild birds in Korea with 96% E and 4% K at amino acid position 627 of PB2. To investigate the genomic characteristics of this clade regarding mammalian adaptation, we studied the replication and transmission of the H5N1 virus in mice.

dogma1138 1y ago

The event as in the research has occurred, and it was 100% lethal to all mammalian subjects and also the conclusion of the research is that the pathway would be applicable to all mammals. So a lab in fact has created a highly contagious flu virus (far higher than regular flu) through gain of function research which has indeed killed 100% of the subjects which contracted it even if they were only mice.

Jtsummers 1y ago
> So a lab in fact has created a highly contagious flu virus This paper does not appear to support that. They indicate the source was an existing, in the wild virus. >> We isolated an HPAI H5N1 clade 2.3.4.4b virus from wild birds in Korea with 96% E and 4% K at amino acid position 627 of PB2. To investigate the genomic characteristics of this clade regarding mammalian adaptation, we studied the replication and transmission of the H5N1 virus in mice.
- dogma1138 1y ago
  That was the gain of function research. They infected mice with a wild strain that already was pre-positioned to better infect mammals used super high viral loads for that then watched as the mutations which promote mammalian infection evolved and exposed challenge mice to the newly developed strain.