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As far as I’ve understood, pure nicotine is not significantly addictive in most people. What is very addictive, though, is the synergistic effect nicotine has
by cluckindan 1y ago
As far as I’ve understood, pure nicotine is not significantly addictive in most people.
What is very addictive, though, is the synergistic effect nicotine has with MAO inhibitors, such as those found in tobacco smoke or vape/gum/pouch flavorings.
- c0nducktr 1y agoI wasn't aware that tobacco alternatives added MAO inhibitors to their flavorings - I thought they were basically, in the case of vapes, propylene glycol and nicotine + "flavor". Is there evidence that the flavors they're including in these are actually MAOIs?
- cluckindan 1y agoMonoamine oxidase inhibitory activity of flavoured e-cigarette liquids https://www.sciencedirect.com/science/article/abs/pii/S0161813X19301007 https://www.sciencedirect.com/science/article/abs/pii/S01618... Reinforcement and MAO-A inhibition in heated tobacco products: flavor and brand variations https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2025.1515519/full https://www.frontiersin.org/journals/psychiatry/articles/10.... Comparison of monoamine oxidase inhibition by cigarettes and modified risk tobacco products https://www.sciencedirect.com/science/article/pii/S2214750019304925 https://www.sciencedirect.com/science/article/pii/S221475001... There is of course variance depending on the exact flavorants used. For example, menthol and mint flavors don’t inhibit MAO, their activity is towards kappa-opioid agonism (induction of dysphoria).
- c0nducktr 1y agoThanks for this, I'll look into these.