3 ms·
What does randomization mean in this context, and why does it fix those problems?
by tines 1y ago
What does randomization mean in this context, and why does it fix those problems?
- NhanH 1y agoPatients are assigned the time for their visits. The time itself is randomized
- ajkjk 1y agohttps://en.wikipedia.org/wiki/Randomized_controlled_trial https://en.wikipedia.org/wiki/Randomized_controlled_trial The same thing it means in every context: that (with enough samples) you can control for confounders.
- tines 1y agoSupposing that patients did better in the morning because, say, the nurses were more alert, no matter how many samples you take you'll find the patients do better in the morning. How does "more samples" help control for confounders rather than just confirm a bias?
- JumpCrisscross 1y ago> How does "more samples" help control for confounders rather than just confirm a bias? I think you're correct that randomising patient assignments doesn't control for provider-side confounders. Curious if the study also randomised nursing assignments.
- ajkjk 1y ago"more samples" is not what controls for confounders. Controlling for confounders is what controls for confounders, which you can only do with enough samples that you can randomize out the effect of the confounder. Whether or not they controlled for nurse-alertness is something you'd have to read the paper (or assume the researchers are intelligent) for.
- tines 1y agoI guess I'm asking, how do you randomize out the confounder in this case.
- ajkjk 1y agoI imagine that that particular confounder is not possible to eliminate via randomization. Perhaps you collect a bunch of data on nurse awakeness--day shift vs night-shift, measuring alertness somehow, or measuring them on other activities known to be influenced by alertness--and then ensure your results don't correlate with that. There is also the mechanistic side: if you have lots of plausible mechanism for what's going on, and you can detect indicators for it that don't seem to correlate with nurse alertness, that's a vote against it mattering. Same if you have of lots of expertise on the ground and they can attest that nurse alertness doesn't seem to have an affect. There are lots of ways, basically, to reach pretty good confidence about that, but they might not be as rigorous as randomized assignments can be.
- bravesoul2 1y agoHave every dose be observed by another doctor?
- kelnos 1y agoPatients in the study are randomly assigned to the early group or the late group. They don't get to schedule their own appointments for whatever time of day they want.
- tines 1y agoHow does this control for the "alert nurses" variable? In that case, patients would do better in the morning, regardless of the patient.
- anigbrowl 1y agoWhy would you assume nurses are scheduled on a 9-5 basis?
- simmerup 1y agoWhy do you think you're going to poke holes in a research article when you've clearly only just heard of the concept and havent even read the article
- tines 1y agoIf I thought I could poke holes in the research, I wouldn't be posting on HN. I'm asking questions to learn because obviously I don't understand :)
- d_tr 1y agoBased on these graphs and the differences in outcomes they show, you are not talking about "alert vs less alert" nurses but about "nurses doing their job vs nurses basically slowly killing dozens of patients".