3 ms·
The original taurine paper in Science was obviously a mess to some of us in the field. They did not even have plausible taurine concentrations. Poor review proc
by robwwilliams 1y ago
The original taurine paper in Science was obviously a mess to some of us in the field. They did not even have plausible taurine concentrations. Poor review process.
There is no reason to supplement with taurine or with resveratrol. Resveratrol debunked firmly by both the Interventions Testing Program in mice (Miller et al 2011, a paper with Sinclair as a coauthor) and earlirr by Timothy Bass and Linda Partridge and colleagues in two widely used model organisms (C elegans anf Drisophila, 2007).
Yes David Sinclair is vocal and has a book: but look at the evidence and compare to rapamycin.
Rapamycin is a drug with strong prolongevity effects at almost any age in both sexes at an appropriate dose to inhibit only mTOR-C1 signaling (4 to 8 mg once per week).
There ARE side effects to almost any drug. And rapamycin will not be a good drug for a subset of humans in some environments. For example rapamycin is one if the last drugs I would take if I was caring for a room full of 5-6 year olds all day. But surprisingly it was a good drug to be taking during COVID-19 if you were older. perhaps by reducing the inflammatory hyper-vigilance that killed so many older humans. See Kaeberlein’s study of 333 biohackers in 2023.
- lentoutcry 1y agowhat about methylene blue? I saw an article around the other day saying basically that it’s mostly hype, but I’ve also heard good things about it.
- giardini 1y agoTough to handle though!8-)) It gets all over the place: stains skin, clothes, most everything else unless you handle it as if you were in a laboratory. Never thought about it before but handling MB in a chem lab might be a very good way to show beginning students how difficult it is to do good lab work and how easily traces of material (and organisms) may pass from one place to another (contact).
- the__alchemist 1y agoThe problem is RM as you know, is the negative effects from immunosuppression. Makes it tougher to justify than others.
- robwwilliams 1y agoYes, at higher doses that affect mTORC2 signaling. At a low intermittent dose it is an immune modulator, not an immune suppressor. Much work on parsing the two. But we do not know much about the role of genetic difference in responses ti this drug, so caution is appropriate.