> Is the propensity to generate IgG4 antibodies specific to mRNA vaccines? Is it a problem? It seems entirely plausible that an mRNA flu vaccine would look amaz

> Is the propensity to generate IgG4 antibodies specific to mRNA vaccines? Is it a problem? It seems entirely plausible that an mRNA flu vaccine would look amazing for one season and less amazing years later. Or not. Flu vaccine effectiveness has been trending slowly downwards for about a decade. I don't recall any established reasons for it, though.