4 ms·
It's definitely an interesting outcome and nice to see such a significant improvement in a clinical trial. And as the article states, there are questions that
by refurb 1y ago
It's definitely an interesting outcome and nice to see such a significant improvement in a clinical trial.
And as the article states, there are questions that aren't addressed - does the reduction in obstructive events change the clinical symptoms such as daytime sleepiness? Intuitively you would think it does, but it should be measured in the trial. I also didn't see anything about adverse events during the trial. Seems like taking a stimulant might cause insomnia in some patients.
> In addition, 22% of the treated patients achieved complete control of the disease, defined as fewer than five airway obstructing events per hour.
This surprised me - 5 obstructive events per hour is "complete control of the disease"?
It looks like this is the clinical trial: https://clinicaltrials.gov/study/NCT05813275 https://clinicaltrials.gov/study/NCT05813275
- AtlasBarfed 1y agoA drug that deals with physical obstruction??? Does it make a sleeper want to be on their side? Is it a weight loss drug? Targeted area antiinflammatory? Cavity dialation? For some snorers,bit would be an improvement based on that standard in my experience. Exercise staying fit. Not getting fat and not drinking alcohol work for me.
- Citizen8396 1y agoIt happens to stimulate nerves in the airway such that it reduces collapse and obstruction. PS: there are many people with OSA with normal BMI who also don't drink.
- binoct 1y agoGlad it worked for you. Not everyone with sleep apnea is an overweight alcoholic. Plenty of drugs help with diseases involving muscle tone, why is that so surprising?
- Elinvynia 1y agoNot every case of sleep apnea is obstructive. With central sleep apnea no amount of weight loss, surgery and repositioning will fix the problem.
- BurningFrog 1y agoFrom the article: > scientists in Boston a decade ago identified a combination of two existing medications that kept the upper airway open by jointly stimulating the relevant muscles, particularly the genioglossus, a workhorse that forms most of the base of the tongue and is critical to keeping the throat open.
- Citizen8396 1y agoFive events is the threshold at which (mild) sleep apnea can be diagnosed.