3 ms·
I thought NSAIDs thinned blood more like apsirin and gave aneurysm risk instead of stroke, and the big risk was stomach bleeds.
by cma 1y ago
I thought NSAIDs thinned blood more like apsirin and gave aneurysm risk instead of stroke, and the big risk was stomach bleeds.
- atombender 1y agoNSAIDs are COX inhibitors which inhibit either COX-1, COX-2, or both. COX-1 is involved in the gastric mucosa, among other roles, which is why blocking it can cause stomach bleeding. COX-2 is involved in maintaining the endothelium of blood vessels, and can increase stroke and infarction risk by stiffening and degrading the lining of the blood vessels over time. Studies are a bit conflicting regarding whether blocking COX-1 or COX-2 is safer, as there seems to be downsides to both, and the difference in risk isn't that clear.