4 ms·

The maximum single dose of paracetamol is 1000 mg, and four doses (4000 mg) in 24 hours. Any more and it's liver damage.

deleted 1y ago
[deleted]
johnisgood 1y ago
I will respond here with links, because my comments regarding NAC and silymarin are getting down-voted. https://emedicine.medscape.com/article/820200-treatment https://emedicine.medscape.com/article/820200-treatment - Treatment for liver damage is NAC (N-acetylcysteine) which is available as a supplement. > N-acetylcysteine (NAC) is the mainstay of therapy for acetaminophen toxicity https://www.ncbi.nlm.nih.gov/books/NBK537183/ https://www.ncbi.nlm.nih.gov/books/NBK537183/ Again, NAC is readily available without prescription. Additionally, see https://www.medscape.com/viewarticle/422884 https://www.medscape.com/viewarticle/422884 for Silymarin (which is found in Milk Thistle). That said, do not exceed the maximum dose. Try ibuprofen, diclofenac, or whatever else, but they are not without risks either. For the record, acetaminophen is the only painkiller you can take on an empty stomach without it causing any GI issues.
- oliwarner 1y ago
  Acetylcysteine isn't magic though. It needs to be administered within 12h and 5% will have a severe anaphylactic-type reaction with risk of respiratory arrest. And the liver can still have been irreparably damaged due to other factors. In the context of this being a miserable way to kill yourself, it's absolutely awful because there is very much a cut off point where you will still be suffering immeasurable pain and no amount of NAC will save you.
  - johnisgood 1y ago
    I did not say it is magic. At any rate, silymarin is actually "magic". It may help you regenerate parts of your liver. See the link I mentioned. Ultimately, what one needs to do is just... not consume high amounts, or too frequently.

4 ms·

The maximum single dose of paracetamol is 1000 mg, and four doses (4000 mg) in 24 hours. Any more and it's liver damage.

by chistev 1y ago

deleted 1y ago
[deleted]
johnisgood 1y ago
I will respond here with links, because my comments regarding NAC and silymarin are getting down-voted. https://emedicine.medscape.com/article/820200-treatment https://emedicine.medscape.com/article/820200-treatment - Treatment for liver damage is NAC (N-acetylcysteine) which is available as a supplement. > N-acetylcysteine (NAC) is the mainstay of therapy for acetaminophen toxicity https://www.ncbi.nlm.nih.gov/books/NBK537183/ https://www.ncbi.nlm.nih.gov/books/NBK537183/ Again, NAC is readily available without prescription. Additionally, see https://www.medscape.com/viewarticle/422884 https://www.medscape.com/viewarticle/422884 for Silymarin (which is found in Milk Thistle). That said, do not exceed the maximum dose. Try ibuprofen, diclofenac, or whatever else, but they are not without risks either. For the record, acetaminophen is the only painkiller you can take on an empty stomach without it causing any GI issues.
- oliwarner 1y ago
  Acetylcysteine isn't magic though. It needs to be administered within 12h and 5% will have a severe anaphylactic-type reaction with risk of respiratory arrest. And the liver can still have been irreparably damaged due to other factors. In the context of this being a miserable way to kill yourself, it's absolutely awful because there is very much a cut off point where you will still be suffering immeasurable pain and no amount of NAC will save you.
  - johnisgood 1y ago
    I did not say it is magic. At any rate, silymarin is actually "magic". It may help you regenerate parts of your liver. See the link I mentioned. Ultimately, what one needs to do is just... not consume high amounts, or too frequently.