3 ms·

impressive for a high schooler but this just adds a protecting group onto tylenol. am i missing something? edit: oh i see. its really blurry but the silyl m

impressive for a high schooler but this just adds a protecting group onto tylenol. am i missing something? edit: oh i see. its really blurry but the silyl modified tylenol is predicted to have good trpv1 binding computationally. afaict no in vitro or in vivo studies were done. could be cool. not sure if diethylethynylphenylsilyl group has good Lipinski properties though (i suspect not) edit: s/aspirin/Tylenol

abrookewood 1y ago
It isn't aspirin - Acetaminophen, also known as N-acetyl-para-aminophenol (APAP) or paracetamol
- throwawaymaths 1y ago
  lol yeah sorry brain too deep into synthetic chemistry bits. thanks.
gus_massa 1y ago
[Very good comment! I'd use the opportunity to add more questions.] How expensive are the steps? They look like advanced steps that can be done in a lab to prepare a few micrograms, but I'm not sure if they can be scaled to industrial production. Why silicon instead of just a carbon? Is it better blocking the docking? Is it better moving the orbital energy levels? Is it as safe as the poster claim?
- throwawaymaths 1y ago
  silicon is not very successful in drugs. https://www.science.org/content/blog-post/silicon-drug-molecules-revisited https://www.science.org/content/blog-post/silicon-drug-molec... that molecule almost certainly fails the ClogP not greater than five lipinski rule (it's too greasy)
  - gus_massa 1y ago
    [Sorry for the delay.] IIUC from the "In the pipeline" article, drugs with silicon are too similar to their equivalent with carbon, and more difficult to make: "so why bother?" Are they using the silicon to avoid the usual rules of substitutions in benzene cycles? Is it possible to do the same trick with carbon? > that molecule almost certainly fails the ClogP not greater than five lipinski rule (it's too greasy) Is it possible to fix it adding some -NH2 (or -COOH ?) group in the second aromatic cycle? [I understand it's a nice science fair project but the article oversell it.]

abrookewood 1y ago

It isn't aspirin - Acetaminophen, also known as N-acetyl-para-aminophenol (APAP) or paracetamol

throwawaymaths 1y ago
lol yeah sorry brain too deep into synthetic chemistry bits. thanks.

gus_massa 1y ago

[Very good comment! I'd use the opportunity to add more questions.] How expensive are the steps? They look like advanced steps that can be done in a lab to prepare a few micrograms, but I'm not sure if they can be scaled to industrial production. Why silicon instead of just a carbon? Is it better blocking the docking? Is it better moving the orbital energy levels? Is it as safe as the poster claim?

throwawaymaths 1y ago
silicon is not very successful in drugs. https://www.science.org/content/blog-post/silicon-drug-molecules-revisited https://www.science.org/content/blog-post/silicon-drug-molec... that molecule almost certainly fails the ClogP not greater than five lipinski rule (it's too greasy)
- gus_massa 1y ago
  [Sorry for the delay.] IIUC from the "In the pipeline" article, drugs with silicon are too similar to their equivalent with carbon, and more difficult to make: "so why bother?" Are they using the silicon to avoid the usual rules of substitutions in benzene cycles? Is it possible to do the same trick with carbon? > that molecule almost certainly fails the ClogP not greater than five lipinski rule (it's too greasy) Is it possible to fix it adding some -NH2 (or -COOH ?) group in the second aromatic cycle? [I understand it's a nice science fair project but the article oversell it.]