The Beckman-Coulter HmX hematology analyzer uses an non-PnP ISA card and MS-DOS software. The connection between the analyzer and the card is a cable as thick a

The Beckman-Coulter HmX hematology analyzer uses an non-PnP ISA card and MS-DOS software. The connection between the analyzer and the card is a cable as thick as my thumb and a connector larger than a Centronix. The software communicates with the card by directly reading and writing to I/O addresses of the card. No modern OS or virtualization would ever allow that. It's why you can't have sound in old MS-DOS games unless you boot DOS or Win9x, or emulate the complete system.