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Ways to present LDL-C and statins benefits vary widely, the graph in the article present statins and reduction of LDL-C as a god send. However some very large
by guerby 1y ago
Ways to present LDL-C and statins benefits vary widely, the graph in the article present statins and reduction of LDL-C as a god send.
However some very large study show a seemingly different story, eg:
https://pmc.ncbi.nlm.nih.gov/articles/PMC9798292/ https://pmc.ncbi.nlm.nih.gov/articles/PMC9798292/
"Association between low-density lipoprotein cholesterol and cardiovascular mortality in statin non-users: a prospective cohort study in 14.9 million Korean adults"
Figure 1 shows a hazard ratio higher for both lower LDL-C and higher LDL-C level, with a large flat part of the curve in between.
Curious if someone has an explanation
- michaeljx 1y agoMy layman take is that like the oil in your car, there is a minimum value you need to be above, and a maximum value you need to stay below. Statin is for treating people that are above the max, so that they drop within acceptable range. Not for lowering the cholesterol to be a slow as possible