The Voyager space probes for sure use visual fixes on guide stars, such as Alpha Centauri (and our own Sun?) to ensure correct orientation. Of course, they don'

The Voyager space probes for sure use visual fixes on guide stars, such as Alpha Centauri (and our own Sun?) to ensure correct orientation. Of course, they don't need to navigate much, since given the relative velocities, their thrusters wouldn't make much difference. And there is a quite-famous scene in Apollo 13 where they literally line-up the Moon itself in the reticule so that their engine burn puts them on exactly the correct trajectory.