4 ms·

Why? [citation needed]

newobj 14y ago
Son was diagnosed as autistic at age 2.5. Many developmental delays including speech, inconsolable screaming, waking up 8+ times a night, and on and on. Literally a day after receiving his first MB12/L5MTHF injection he started talking. In the year and a half since, along with other supplements (fish oils, B6, probiotics, TMG, Zinc, etc -- all over the counter), and cutting out soy/gluten/dairy/eggs etc he's basically a totally typical kid now - he has no therapies, goes to a normal school, is advanced in some areas. For myself, I lived a long time with low-grade but chronic anxiety and depression and after all this went down finally had some testing done on myself and found out I am homozygous for the C677T mutation, which means my body can't make methyl-B12 or methyl-folate. (Homozygous is 60-70% reduced efficiency in the reaction). I started supplementing with the same (though I get my MB12/L5MTHF orally, not injected), and for the first time feel like a cloud has been lifted. It's been amazing. Turns out my mom, her dad, and so on and so forth were all B-12 anemic. It took my son being severely impacted for ME to finally get tested to finally figure out for the whole family what the problem is. The interesting part is when the methylation process is disrupted by this mutation one of things whose production suffers is glutathione. It's a very important antioxidant (http://www.huffingtonpost.com/dr-mark-hyman/glutathione-the-mother-of_b_530494.html http://www.huffingtonpost.com/dr-mark-hyman/glutathione-the-...). Thinking about one of the major detoxifiers of the body being broken is interesting in light of the seemingly tenuous links between "autism" and vaccines etc. In short my armchair speculation is that there's likely a large overlap between undiagnosed 677T/1298C mutation sufferers and "autism" and when you think about injecting those kids with things that contain known irritants causing even more inflammation that the body can't clean out, it's not hard to imagine why it seems like they "cause" autism. To me it's simply more like pulling the trigger on a gun that's already been loaded and pointed to your head. Homozygous 677T mutation rate is somewhere between 1-15% in the US.
- SoftwareMaven 14y ago
  This is...fascinating...and something I really need to study more. Given I have a family history of colon cancer, leukemia, and schizophrenia (all of which show up in the wikipedia article that is a top DDG result of "C677T mutation"[1]), there might be something more I have to care about here. Do you have other references I could follow up on? 1. https://en.wikipedia.org/wiki/MTHFR https://en.wikipedia.org/wiki/MTHFR
  - danielweber 14y ago
    Be very careful listening to anecdotes. Autism is a delay, so you could do something useless like crystal therapy and have the child get better afterwards, and -- based on standard human biases we all have -- think that the crystal therapy cured him. If you want to see what happens with an actual double-blind experiment, check out http://www.ncbi.nlm.nih.gov/pubmed/20804367 http://www.ncbi.nlm.nih.gov/pubmed/20804367

Son was diagnosed as autistic at age 2.5. Many developmental delays including speech, inconsolable screaming, waking up 8+ times a night, and on and on. Literally a day after receiving his first MB12/L5MTHF injection he started talking. In the year and a half since, along with other supplements (fish oils, B6, probiotics, TMG, Zinc, etc -- all over the counter), and cutting out soy/gluten/dairy/eggs etc he's basically a totally typical kid now - he has no therapies, goes to a normal school, is advanced in some areas. For myself, I lived a long time with low-grade but chronic anxiety and depression and after all this went down finally had some testing done on myself and found out I am homozygous for the C677T mutation, which means my body can't make methyl-B12 or methyl-folate. (Homozygous is 60-70% reduced efficiency in the reaction). I started supplementing with the same (though I get my MB12/L5MTHF orally, not injected), and for the first time feel like a cloud has been lifted. It's been amazing. Turns out my mom, her dad, and so on and so forth were all B-12 anemic. It took my son being severely impacted for ME to finally get tested to finally figure out for the whole family what the problem is. The interesting part is when the methylation process is disrupted by this mutation one of things whose production suffers is glutathione. It's a very important antioxidant (http://www.huffingtonpost.com/dr-mark-hyman/glutathione-the-mother-of_b_530494.html http://www.huffingtonpost.com/dr-mark-hyman/glutathione-the-...). Thinking about one of the major detoxifiers of the body being broken is interesting in light of the seemingly tenuous links between "autism" and vaccines etc. In short my armchair speculation is that there's likely a large overlap between undiagnosed 677T/1298C mutation sufferers and "autism" and when you think about injecting those kids with things that contain known irritants causing even more inflammation that the body can't clean out, it's not hard to imagine why it seems like they "cause" autism. To me it's simply more like pulling the trigger on a gun that's already been loaded and pointed to your head. Homozygous 677T mutation rate is somewhere between 1-15% in the US.

SoftwareMaven 14y ago
This is...fascinating...and something I really need to study more. Given I have a family history of colon cancer, leukemia, and schizophrenia (all of which show up in the wikipedia article that is a top DDG result of "C677T mutation"[1]), there might be something more I have to care about here. Do you have other references I could follow up on? 1. https://en.wikipedia.org/wiki/MTHFR https://en.wikipedia.org/wiki/MTHFR
- danielweber 14y ago
  Be very careful listening to anecdotes. Autism is a delay, so you could do something useless like crystal therapy and have the child get better afterwards, and -- based on standard human biases we all have -- think that the crystal therapy cured him. If you want to see what happens with an actual double-blind experiment, check out http://www.ncbi.nlm.nih.gov/pubmed/20804367 http://www.ncbi.nlm.nih.gov/pubmed/20804367