4 ms·
RARα pathway operates in cell development eg of blood cells and in apoptosis, implicated in some cancers. Long-term safety seems doubtful. Offspring could be a
by w10-1 2y ago
RARα pathway operates in cell development eg of blood cells and in apoptosis, implicated in some cancers.
Long-term safety seems doubtful. Offspring could be affected. In a rational world there would be no volunteers for the trials.
- patall 2y agoCould also positively affect offspring if spermatogenesis is blocked at the right step, stopping the gamete progenitors from accumulating somatic mutation. The majority of rare genetic diseases arising from de-novo mutations has its origin in the fathers gamete formation (with increasing risk (i.e accumulation of mutations) at older paternal age). Maybe this could block/slow down this process (i.e cell division) and in 20 years all males that still may want to have kids will take a RARα blocker.
- cantrecallmypwd 2y agoWouldn't it be simpler to bank sperm when a man turns, say, 18 rather than take a risk on what an unproven medication might or might not do?
- giantg2 2y agoDoes this actually stop spermatogenesis, or does it just result in non-viable gamete production?