4 ms·

I had this same experience, but I have not continued to take the medication after a short experiment. I found I could get a similar outcome (subjective experien

I had this same experience, but I have not continued to take the medication after a short experiment. I found I could get a similar outcome (subjective experience) through my food selection Today I’ve eaten around 2kg of vegetables today (zucchini, capsicum, eggplant, cauliflower, spinach) all of which was under 500 calories, and I’ve eaten fish. If I eat a massive amount of vegetables and get ~200g protein, I don’t feel I’m depriving myself and am satiated on under 2000 calories, previously I would typically eat over 3000 on a normal day. As for people lacking willpower, the genetics of hunger mean all of us experience vastly different levels of hunger. You might be interested to read about the family in Pakistan who could not produce a relevant hormone leptin, and the toddlers driven to fighting by insatiable hunger to steal food from each other, and the dramatic change in their lives after medical intervention with leptin injections

wonderwonder 1y ago
My brother's family has done something similar although in a different direction. They have been strictly carnivore for several years now. Able to eat large amounts of food while keeping calories low and feeling satiated. It's worked well for them. I'll look at that study you mentioned, thank you.
- monkeycantype 1y ago
  leptin deficiency is rare, so supplementation does not produce an effect in most people. https://www.nejm.org/doi/full/10.1056/NEJM199909163411204 https://www.nejm.org/doi/full/10.1056/NEJM199909163411204 There is more information about the family involved out there, but I can't remember where I read about it. A thing I found interesting about the genetics of hunger, is the concept of mongenetic, v polygenetic traits Monogenetic traits - a variation in a single gene is has an observed often severe impact. Polygenetic traits - variations in a large number of genes and environmental are contributing In reality these traits exist on a spectrum of severity. The more sublte the impact of a gene the more people you need to study to tease out the influence of the gene, so monogenetic traits tend to be discovered first.

wonderwonder 1y ago

My brother's family has done something similar although in a different direction. They have been strictly carnivore for several years now. Able to eat large amounts of food while keeping calories low and feeling satiated. It's worked well for them. I'll look at that study you mentioned, thank you.

monkeycantype 1y ago
leptin deficiency is rare, so supplementation does not produce an effect in most people. https://www.nejm.org/doi/full/10.1056/NEJM199909163411204 https://www.nejm.org/doi/full/10.1056/NEJM199909163411204 There is more information about the family involved out there, but I can't remember where I read about it. A thing I found interesting about the genetics of hunger, is the concept of mongenetic, v polygenetic traits Monogenetic traits - a variation in a single gene is has an observed often severe impact. Polygenetic traits - variations in a large number of genes and environmental are contributing In reality these traits exist on a spectrum of severity. The more sublte the impact of a gene the more people you need to study to tease out the influence of the gene, so monogenetic traits tend to be discovered first.