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I had to guess who "most famous podcaster is" and check was DMT means. https://knowyourmeme.com/memes/thats-crazy-man-have-you-ever-done-dmt https://knowyourmeme.com/memes/thats-crazy-man-have-you-ever... "[Joe] Rogan reacts to a variety of unrelated statements by saying "That's crazy. Have you ever tried DMT?", referring to dimethyltryptamine, a chemical consumed as a psychedelic drug."