4 ms·

The new doping trick – and why scientists fear athletes are already using it

26 points by mhb 2y ago

Alifatisk 2y ago
Paywall.
bostonwalker 2y ago
Doping potential aside, this sounds like a very promising area of research. The article mentions increased endurance, peak performance, and anti-aging potential. What are the downsides to having more mitochondria in our cells and why did we evolve to have the levels we currently have?
- mrbluecoat 2y ago
  > run 50 per cent longer and 50 per cent quicker Sounds like a candidate for army research to me..
jtbayly 2y ago
https://archive.vn/2025.02.17-085311/https://www.telegraph.co.uk/news/2025/02/14/new-doping-trick-why-scientists-fear-athletes-already-using/ https://archive.vn/2025.02.17-085311/https://www.telegraph.c...
scotty79 2y ago
What I was curious about a decade ago was if one could transplant mitochondria from bats into mice (and some day humans) and what effect would it have on their longevity. One of the things that contribute to aging is collateral damage caused by mitochondria operation. Bats due to energy requirements of flight have quite incredible mitochondria. It probably wouldn't be easy as there's some cellular genetics that influences how given species cells interact with their mitochondria, but recent gene manipulation techniques and successes like "dire wolves" and "woolly mice" give me hope. Mitochondria are very important and they do gradually wear out. It's so important to have them fresh that all of your mitochondria came from the egg of your mother and were produced in her early development before she was even born and were kept dormant until fertilization so you can get a fresh new set of mitochondria. Male mitochondria that aged (because sperm is produced in adults) and get additionally used up as the sperm moves are completely discarded during the fertilization.
- Ccecil 2y ago
  And that is how the new Batman got his Spiderman backstory...
DeathArrow 2y ago
Not an athlete but fur sure I would like to try this if there aren't significant side effects.
sharpshadow 2y ago
Some more explaination and the mitochondrial isolation protocol can indeed be found on his website[0]. 0. https://sites.google.com/mccullylab.org/mccullylab https://sites.google.com/mccullylab.org/mccullylab

26 points by mhb 2y ago

Paywall.

Doping potential aside, this sounds like a very promising area of research. The article mentions increased endurance, peak performance, and anti-aging potential. What are the downsides to having more mitochondria in our cells and why did we evolve to have the levels we currently have?

mrbluecoat 2y ago
> run 50 per cent longer and 50 per cent quicker Sounds like a candidate for army research to me..

jtbayly 2y ago

https://archive.vn/2025.02.17-085311/https://www.telegraph.co.uk/news/2025/02/14/new-doping-trick-why-scientists-fear-athletes-already-using/ https://archive.vn/2025.02.17-085311/https://www.telegraph.c...

scotty79 2y ago

What I was curious about a decade ago was if one could transplant mitochondria from bats into mice (and some day humans) and what effect would it have on their longevity. One of the things that contribute to aging is collateral damage caused by mitochondria operation. Bats due to energy requirements of flight have quite incredible mitochondria. It probably wouldn't be easy as there's some cellular genetics that influences how given species cells interact with their mitochondria, but recent gene manipulation techniques and successes like "dire wolves" and "woolly mice" give me hope. Mitochondria are very important and they do gradually wear out. It's so important to have them fresh that all of your mitochondria came from the egg of your mother and were produced in her early development before she was even born and were kept dormant until fertilization so you can get a fresh new set of mitochondria. Male mitochondria that aged (because sperm is produced in adults) and get additionally used up as the sperm moves are completely discarded during the fertilization.

Ccecil 2y ago
And that is how the new Batman got his Spiderman backstory...

DeathArrow 2y ago

Not an athlete but fur sure I would like to try this if there aren't significant side effects.

sharpshadow 2y ago

Some more explaination and the mitochondrial isolation protocol can indeed be found on his website[0]. 0. https://sites.google.com/mccullylab.org/mccullylab https://sites.google.com/mccullylab.org/mccullylab