The paper describe the effect at 1.4% saccharine in solution. The oral LD50 in mice is 17 g/kg. https://pubchem.ncbi.nlm.nih.gov/compound/Saccharin#section=Ac

The paper describe the effect at 1.4% saccharine in solution. The oral LD50 in mice is 17 g/kg. https://pubchem.ncbi.nlm.nih.gov/compound/Saccharin#section=Acute-Effects https://pubchem.ncbi.nlm.nih.gov/compound/Saccharin#section=... Maybe ok for topical application?