3 ms·

> L-theanine has a calming effect, it is quite well known. The evidence for this in humans is very weak.

• danielscrubs 2y ago
  Here is a randomized, triple blind study: https://pubmed.ncbi.nlm.nih.gov/34562208/ https://pubmed.ncbi.nlm.nih.gov/34562208/ ”had significant positive effects on brainwaves, salivary cortisol, and self-reported state anxiety compared to the placebo in response to an acute stress challenge. These changes are indicative of relaxation in the brain and suggest a calming response in a moderately stressed but otherwise healthy population”
  • q3k 2y ago
    n=16. This isn't even worthy of classifying as a Phase I trial. Efficacy studies generally _start_ at n=100. Drawing any conclusions on efficacy from this kind of sample size is simply unscientific.