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There is abundant literature on SNP data <> disease correlation. Here's an example (fictional preview) report from Promethease, which you can run on your SNP d

There is abundant literature on SNP data <> disease correlation. Here's an example (fictional preview) report from Promethease, which you can run on your SNP data you download from 23andme: https://files.snpedia.com/reports/promethease_data/genome_Mike_Spear_pooled_ui2.html https://files.snpedia.com/reports/promethease_data/genome_Mi... eg. > 1.42x risk of Autism > 1.3x to 11.5x Increased risk of autoimmune thyroid disease > 1.3x higher risk of ER+ breast cancer > 2 - 3x higher prostate cancer risk if routinely exposed to the pesticide fonofos > 1.5x - 2x increased risk for cervical cancer, HNSCC, and breast cancer > 2x risk of Alzheimer's disease > Lack of empathy? You have a SNP in the oxytocin receptor which may make you less empathetic than other people. > Increased risk of Multiple Sclerosis. > HLA-DRB11501 carrier; higher multiple sclerosis risk Rs3135391(C;T) is highly correlated with the HLA-DRB11501 allele. There is a 3x higher risk of multiple sclerosis associated with the (C;T) genotype. > 1.4x higher risk of lupus increased risk of Systemic lupus erythematosus. (And on and on...) This is stuff that 23andme can't legally show you, and many of the studies are small and inconclusive. But many of the disease markers are noteworthy. Just click through to the literature, eg. https://www.snpedia.com/index.php/Rs429358 https://www.snpedia.com/index.php/Rs429358

tptacek 2y ago
You said "IQ, agreeableness, neurodegeneration, schizophrenia [fine, whatever], personality type". Science fiction.
robwwilliams 2y ago
Yes, those are tiny relative risk scores for large diverse (messy) POPULATIONS. They are absolutely NOT individual predictions. Even the most sophisticated polygenic risk score are jokes for most traits—-particularly psychosocial traits. You want actionable information— a 30 minute interview.
dragonwriter 2y ago
None of those are particularly useful on an individual level. E.g.: - 1.42x risk of Autism Okay, great, the population incidence is about 1 in 36, so 1.42x risk is about 1 in 25. What possible actionable use is this? It's not even particularly useful input to "should I follow up with some kind of actual assessment". But even that and the other not-particularly-useful numeric risk multipliers are better than: - You have a SNP in the oxytocin receptor which may make you less empathetic than other people. At this level of specificity, you may as well be consulting a magic 8-ball.

tptacek 2y ago

You said "IQ, agreeableness, neurodegeneration, schizophrenia [fine, whatever], personality type". Science fiction.

robwwilliams 2y ago

Yes, those are tiny relative risk scores for large diverse (messy) POPULATIONS. They are absolutely NOT individual predictions. Even the most sophisticated polygenic risk score are jokes for most traits—-particularly psychosocial traits. You want actionable information— a 30 minute interview.

dragonwriter 2y ago

None of those are particularly useful on an individual level. E.g.: - 1.42x risk of Autism Okay, great, the population incidence is about 1 in 36, so 1.42x risk is about 1 in 25. What possible actionable use is this? It's not even particularly useful input to "should I follow up with some kind of actual assessment". But even that and the other not-particularly-useful numeric risk multipliers are better than: - You have a SNP in the oxytocin receptor which may make you less empathetic than other people. At this level of specificity, you may as well be consulting a magic 8-ball.